mRNA modification orchestrates cancer stem cell fate decisions

Despite their small numbers, cancer stem cells play a central role in driving cancer cell growth, chemotherapeutic resistance, and distal metastasis. Previous studies mainly focused on how DNA or histone modif...
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research

Related Links:

This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study investigated the effect of differentiation on the expression of two immune checkpoint inhibitors, human leukocyte antigen‑G (HLA‑G) and programmed death ligand‑1 (PD‑L1). Two cancer cell lines (OVCAR‑3‑NIH and KATO‑III) were treated with adipocyte and neurocyte differentiation media for 14 days. Bone‑marrow derived mesenchymal stem cells (BM‑MSCs) were used as control healthy stem cells. We found that the cancer cell lines (OVCAR‑3‑NIH and KATO‑III) when subjected to differentiation lost their proliferation ability. BM‑MSC proliferation was not halted but was decreased in the adipo...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Inhibitory effect of therapeutic genes, cytosine deaminase and interferon‑β, delivered by genetically engineered stem cells against renal cell carcinoma. Oncol Rep. 2020 Mar 30;: Authors: Kim GS, Kim SM, Kim SU, Lee G, Choi KC Abstract Although the effects of stem cells expressing anticancer genes on tumor growth have been demonstrated by many researchers in various types of cancer, relatively few studies have investigated their inhibitory effects on cancer metastasis. In the present study, we examined the inhibitory effects of cytosine deaminase (CD)/5‑fluorocytosine (5‑FC) and interferon...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Publication date: Available online 2 April 2020Source: Stem Cell ReportsAuthor(s): Nina Maenhoudt, Charlotte Defraye, Matteo Boretto, Ziga Jan, Ruben Heremans, Bram Boeckx, Florian Hermans, Ingrid Arijs, Benoit Cox, Els Van Nieuwenhuysen, Ignace Vergote, Anne-Sophie Van Rompuy, Diether Lambrechts, Dirk Timmerman, Hugo Vankelecom
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
saharu Seno The tumor microenvironment (TME) has an essential role in tumor initiation and development. Tumor cells are considered to actively create their microenvironment during tumorigenesis and tumor development. The TME contains multiple types of stromal cells, cancer-associated fibroblasts (CAFs), Tumor endothelial cells (TECs), tumor-associated adipocytes (TAAs), tumor-associated macrophages (TAMs) and others. These cells work together and with the extracellular matrix (ECM) and many other factors to coordinately contribute to tumor growth and maintenance. Although the types and functions of TME cells are well u...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Progeroid mice with DNA repair deficiencies exhibit an accelerated formation of senescent cells and manifestation of age-related conditions. This class of animal model has been used in research relating to cellular senescence in order to cost-effectively demonstrate that targeted removal of senescent cells is beneficial. However, one still needs to be careful when drawing conclusions based on their peculiar biochemistry. Progeria of this nature is quite unlike normal aging at the detail level. Cells become senescent in response to reaching the Hayflick limit, tissue injury, molecular damage, or a toxic environment. ...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
By CHADI NABHAN MD, MBA, FACP One harsh Chicago winter, I remember calling a patient to cancel his appointment because we had deemed it too risky for patients to come in for routine visits—a major snowstorm made us rethink all non-essential appointments. Mr. Z was scheduled for his 3-month follow-up for an aggressive brain lymphoma that was diagnosed the prior year, during which he endured several rounds of intense chemotherapy. His discontent in hearing that his appointment was canceled was palpable; he confessed that he was very much looking forward to the visit so that he could greet the nurses, front-desk sta...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 Hospitals Medical Practice Physicians Chadi Nabhan Clinical Trials coronavirus drug dosing Oncology Pandemic Source Type: blogs
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC00472C, CommunicationSourav Acharya, Subhashis Ghosh , Moumita Maji, Ajmal Roshan Unniram Parambil, Sandeep Singh, Arindam Mukherjee Cancer stem cell (CSCs) contributes to the poor therapeutic efficacy and cancer relapse which limits the application of conventional chemotherapy. Herein, we have reported six Ru complexes of mesalazine based... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
British Journal of Cancer, Published online: 03 April 2020; doi:10.1038/s41416-020-0825-7Chemotherapy exacerbates ovarian cancer cell migration and cancer stem cell-like characteristics through GLI1
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
In this study, we used a combination of patient data, in vitro, and in vivo models to investigate the effect of TIE2 in the dormancy of bone metastases. In BCa patients, we found that a higher TIE2 expression is associated with an increased time to metastases and survival. In vitro, TIE2 decreased cell proliferation as it increased the expression of cyclin-dependent kinase inhibitors CDKN1A and CDKN1B and arrested cells in the G0/G1 phase. Expression of TIE2 also increased the resistance to the chemotherapeutic 5-Fluorouracil. In mice, TIE2 expression reduced tumor growth and the formation of osteolytic bone metastasis. To...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
More News: Cancer | Cancer & Oncology | Stem Cell Therapy | Stem Cells | Study