Rhinosinusitis Diagnosis and Management: The Hoops and Hurdles

In my nearly 3 decades of clinical practice as an allergist/immunologist, I can think of no other condition more difficult and frustrating than chronic rhinosinusitis (CRS). Most of my CRS patients were refractory to treatment. At times, in frustration, I would “throw the kitchen sink at them” (ie, oral corticosteroids, topical and oral antibiotics, topical antifungal agents) to try to improve their quality of life. There are several reasons CRS diagnosis and management are so challenging. CRS is a complex, heterogeneous disease with several subgroups (also known as endotypes), which are defined by biomarkers that reflect their biological mechanism.
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Tags: Foreword Source Type: research