Antimicrobial Activity of Ceftolozane-Tazobactam and Comparators When Tested against Clinical Isolates of Haemophilus influenzae from the United States and Europe.

Antimicrobial Activity of Ceftolozane-Tazobactam and Comparators When Tested against Clinical Isolates of Haemophilus influenzae from the United States and Europe.
Antimicrob Agents Chemother. 2020 Feb 24;:
Authors: Sader HS, Carvalhaes CG, Duncan LR, Shortridge D
Abstract
Nine hundred Haemophilus influenzae clinical isolates from 83 U.S. and European medical centers were tested for susceptibility by reference broth microdilution methods against ceftolozane-tazobactam and comparators. Results were stratified by β-lactamase production and infection type. Overall, ceftolozane-tazobactam MIC50/90 values were 0.12/0.25 mg/L and 99.0% of isolates were inhibited at the susceptible breakpoint of ≤0.5 mg/L; the highest MIC value was only 2 mg/L. Our results support using ceftolozane-tazobactam to treat H. influenzae infections.
PMID: 32094135 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - February 23, 2020 Category: Microbiology Authors: Sader HS, Carvalhaes CG, Duncan LR, Shortridge D Tags: Antimicrob Agents Chemother Source Type: research