Efficacy and safety of different ticagrelor regimens versus clopidogrel in patients with coronary artery disease: a retrospective multicenter study (SUPERIOR).
This study (NCT03381742) retrospectively analyzed the data from 11 hospitals on 3,043 patients with coronary artery disease, who received C75QD, T90BID, ticagrelor 45 mg BID (T45BID), or ticagrelor 90 mg QD (T90QD). Compared with C75QD, both T45BID and T90QD showed significantly higher inhibition of platelet aggregation (P
Benign M üllerian papillomas have been described in patients as a rare tumor of the female genital tract. Symptoms typically arise as pre-pubertal vaginal bleeding with findings of a polypoid mass originating in the cervix or vagina. However, a vaginal squamous papilloma in a menarchal patient has not yet b een described in the literature. We will describe a case of recurrent squamous vaginal lesion in a 12 year old female.
We present baseline results of an ongoing longitudinal study examining menstrual suppression and QoL in GM youth. The objective of the current analysis was to examine menstrual related symptoms and menstrual suppression method choice in GM youth at time of method initiation.
While squamous cell papillomas (SCPs) are commonly reported in the literature to occur in adults at the larynx, oral cavity, oropharynx and anus, recent reports of occurrence in the vaginal canal are rare. With the rise in HPV related cancers, as well as the increased incidence of high risk types of HPV in SCP, it is becoming more important to be able to detect and genotype HPV for management of such cases. Furthermore, recognition of this entity is important in the evaluation of any vaginal mass causing prepubertal bleeding.
Ehlers-Danlos Syndrome (EDS) is a connective tissue disorder resulting in abnormal collagen synthesis leading to skin, joint, ligament, blood vessel and organ abnormalities. Studies in adults show an association with heavy menstrual bleeding, dysmenorrhea, and other gynecologic concerns, but there are no studies looking at gynecologic problems an adolescent population with EDS. We aimed to survey gynecologic complaints and management in a pediatric and adolescent population with EDS.
Lichen sclerosus is a benign dermatologic condition of the anogenital region that is most commonly seen in prepubescent girls and post-menopausal women. Presentation is variable and includes vulvar itching, infections of the urinary tract, urinary incontinence or vulvovaginal bleeding. Long term sequelae are often minimal, however, without adequate identification and treatment girls may experience future sexual dysfunction or changes in vulvar architecture.
Genital self-mutilation (GSM) has been published in males however less in females. Rates of self-harm in females, especially adolescents are known to be higher than male counterparts, but GSM although prevalent is not well documented. Few case reports have been written in regards to women with GSM, none in a prepubertal female. Here we present a case involving an 8 year old with prepubertal vaginal bleeding that was followed for over 3 years secondary to a late disclosure of GSM.
The Council for Resident Education in Obstetrics and Gynecology specifies that Ob-Gyn residents receive education and training regarding pre-pubertal vaginal bleeding, including obtaining a pertinent history, performing an age-appropriate physical examination, and performing and interpreting tests for a pediatric patient. However, Ob-Gyn residents, receive minimal training in the field of pediatric and adolescent gynecology (PAG), including how to perform a pre-pubertal genital exam and vaginoscopy.
Uterine fibroids are a common cause of abnormal uterine bleeding in adult women, but are extremely rare in the adolescent years, with a reported incidence of
This work has been previously published.
We examined reasons for discontinuation of first-line therapies among adolescents and young adults with HMB.