Self-assembling cashew gum-GRAFT-POLYLACTIDE copolymer nanoparticles as a potential amphotericin b delivery matrix.

Self-assembling cashew gum-GRAFT-POLYLACTIDE copolymer nanoparticles as a potential amphotericin b delivery matrix. Int J Biol Macromol. 2020 Feb 22;: Authors: Richter AR, Carneiro MJ, de Sousa NA, Pinto VPT, Freire R RS, de Sousa JS, de Fátima Souza Mendes J, Dos Santos Fontenelle RO, Feitosa JPA, Paula HCB, Goycoolea FM, de Paula RCM Abstract Amphotericin B is an antibiotic used in the treatment of fungal disease and leishmania; however, it exhibits side effects to patients, hindering its wider application. Therefore, nanocarriers have been investigated as delivery systems for amphotericin B (AMB) in order to decrease its toxicity, besides increase bioavailability and solubility. Amphiphilic copolymers are interesting materials to encapsulate hydrophobic drugs such as AMB, hence copolymers of cashew gum (CG) and l-lactide (LA) were synthesized using two different CG:LA molar ratios (1:1 and 1:10). Data obtained revealed that copolymer nanoparticles present similar figures for particle sizes and zeta potentials; however, particle size of encapsulated AMB increases if compared to unloaded nanoparticles. The 1:10 nanoparticle sample has better stability although higher polydispersity index (PDI) if compared to 1:1 sample. High amphotericin (AMB) encapsulation efficiencies and low hemolysis were obtained. AMB loaded copolymers show lower aggregation pattern than commercial AMB solution. AMB loaded nanoparticles show antifungal activit...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research