Combination of copper ions and nucleotide generates aggregates from prion protein fragments in the N-terminal domain.

CONCLUSION: The phosphate group on the adenine-linked ribose moiety of adenine nucleotides and pyridine nucleotides is presumed to be essential for the observed effect on aggregation. Efficient aggregation requires the presence of the four octarepeats. These insights may be helpful in the eventual development of therapeutic agents against prion-related disorders.
PMID: 32096738 [PubMed - as supplied by publisher]

Source: Protein and Peptide Letters - February 24, 2020 Category: Biochemistry Authors: Shiraishi N, Hirano Y Tags: Protein Pept Lett Source Type: research