MiR-30c-5p inhibits high glucose-induced EMT and renal fibrogenesis by down-regulation of JAK1 in diabetic nephropathy.

CONCLUSIONS: MiR-30c-5p evidently inhibited HG-induced EMT and renal fibrogenesis by down-regulation JAK1 in DN, providing a promising therapeutic strategy for the treatment of DN. PMID: 32096183 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

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Authors: Kawada T PMID: 32216510 [PubMed - as supplied by publisher]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
CONCLUSIONS: The well-documented risk factors are age, history of diabetes mellitus and renal failure, multivessel coronary artery disease on angiography and time from pain onset to first medical contact. The less conventional risk predictors are total amount of contrast agent administered during invasive procedures and patient radiation exposure during the procedures. PMID: 32207699 [PubMed - as supplied by publisher]
Source: Kardiologia Polska - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
Abstract As of February 29, 2020, more than 85,000 cases of coronavirus disease 2019 (COVID-19) have been reported from China and 53 other countries with 2,924 deaths. On January 30, 2020, the first laboratory-confirmed case of COVID was reported from Kerala, India. In view of the earlier evidence about effectiveness of repurposed lopinavir/ritonavir against severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus (CoV), as well as preliminary docking studies conducted by the ICMR-National Institute of Virology, Pune, the Central Drugs Standard Control Organization approved ...
Source: Indian J Med Res - Category: Research Authors: Tags: Indian J Med Res Source Type: research
This study aimed to identify the vitamin D level below which mortality increases in HD patients.Methods: A cohort of HD patients enrolled from January 2014 to January 2017 was evaluated. The variables were analyzed according to the season, namely, summer, winter, and annual average, mortality was the primary outcome. The patients were assigned to vitamin D quintiles, and multivariate Cox regression analysis adjusted for age, ethnicity, gender, body mass index (BMI), inhibitors of the renin-angiotensin system, statin, calcitriol, and antiplatelet drugs use, hemodialysis vintage, hypertension, diabetes mellitus, atherosclero...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Conclusions: Most patients with DN subjected to renal biopsy were in class IV, and AIN was the most common NDRD. Only tubulointerstitial chronicity correlated with low eGFR.
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Conclusions: Although significant data support the use of MRA in HFrEF, utilization is lower than previously estimated.
Source: American Journal of Therapeutics - Category: Drugs & Pharmacology Tags: Original Investigations Source Type: research
Diabetes mellitus (DM) is a globally chronic condition that currently affects over 422 million people worldwide, a number that has been estimated to grow to 552 million by 2030 [1,2]. Saudi Arabia is one of the nations with the highest DM prevalence regionally and internationally [3]. Hypertension (HT) is more common in patients with diabetes than in those without diabetes [4,5]. The co-occurrence of HT has a substantial clinical effect of producing a poor outcome for patients with diabetes. Complications such as renal failure, stroke, heart disease, peripheral vascular disease, and mortality are the most adverse outcomes ...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Authors: Di Lullo L, Bellasi A, Guastamacchia E, Triggiani V, Ronco C, Lavalle C, Di Iorio BR, Russo D, Cianciolo G, La Manna G, Settembrini S Abstract Diabetes mellitus, with its complications, is one of the major health problems in economically developed countries and its prevalence is constantly increasing. Kidneys and heart involvement represent main comorbidities in diabetic patients often leading to organ's failure. The treatments available until a few years ago are often associated with hypoglycemia, weight gain, gastro-intestinal disorders and other side effects together with serious averse effects on renal...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
Background: To evaluate differences between older women and men with HIV regarding HIV variables, comorbidity, physical function, and quality of life (QOL). Setting: The Modena HIV clinic. Methods: Prospective cohort study. Cross-sectional analysis. Patients>50 years were included, stratified by sex. We recorded sociodemographic data, comorbidities, variables related to HIV infection, frailty, data on body composition, physical function, physical activity, and QOL. Results: We evaluated 1126 older adults with HIV, of which 284 (25.2%) were women. Median age was 55 (IQR 6) years. There were significant differe...
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Clinical Science Source Type: research
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