Fructose-induced alterations of glucose and lipid homeostasis: progressive organ dysfunction leading to metabolic diseases or mere adaptive changes?

In the 1970s and 1980s, the monosaccharide fructose, because of its low glycemic effect, attracted much interest as a potential sweetener for patients with diabetes mellitus (1). Many decades later, its widespread use in the food supply, both as a component of sucrose as well as in high-fructose corn syrup, has become a major suspect in the current epidemic of obesity, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and cardiovascular diseases (2).
Source: American Journal of Clinical Nutrition - Category: Nutrition Source Type: research