Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti-Alzheimer's Disease Agents.

This study was therefore aimed to assess the in vitro bioactivities associated with the LP EO. The EO was separated by hydrodistillation from the aerial parts of LP plants and analyzed for its antioxidant, antimicrobial, anticholinesterase, and antilipase activities. GC-MS was used for phytochemical analysis. The chemical analysis of the EO composition revealed 25 constituents, of which carvacrol (65.27%) was the most abundant. EO exhibited strong antioxidant (IC50 0.16-0.18 μL/mL), antiacetylcholinesterase (IC50 0.9 μL/mL), antibutyrylcholinesterase (IC50 6.82 μL/mL), and antilipase (IC50 1.08 μL/mL) effects. The EO also demonstrated high antibacterial activity with the highest susceptibility observed for Staphylococcus aureus with 95.7% inhibition. The EO was shown to exhibit strong inhibitory activity against Candida albicans (MIC 0.47 μL/mL). The EO was also shown to possess strong antidermatophyte activity against Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum (EC50 0.05-0.06 μL/mL). The high antioxidant, enzyme inhibitory, and antimicrobial potentials of the EO can, therefore, be correlated with its high content of monoterpenes, especially carvacrol, as shown by its comparable bioactivities indicators results. This study provided new insights into the composition and bioactivities of LP EO. Our finding revealed evidence that LP EO makes a valuable natural sourc...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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CONCLUSIONS BCG vaccination in the morning induces stronger trained immunity and adaptive responses compared with evening vaccination. Future studies should take vaccine administration time into account when studying specific and nonspecific effects of vaccines; early morning should be the preferred moment of BCG administration.FUNDING The Netherlands Organization for Scientific Research, the European Research Council, and the Danish National Research Foundation.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
(Pennington Biomedical Research Center) More than 18 percent of US adults do not know whether they will have enough to eat from day to day, and the numbers are worse for Hispanics, Blacks, people with obesity, and women, a new report shows.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Publication date: Available online 20 September 2020Source: American Journal of Infection ControlAuthor(s): Melanie Randall, Thomas Minahan, Michael Mesisca, Silvia Gnass
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Conclusions: Due to the perceived shortcomings of alternative approaches, the use of clear aligners for correcting AC in mixed dentition should be considered as a comfortable and well tolerated appliance for young patients.RESUMO Introdu ção: A mordida cruzada anterior (MCA) é definida como uma relação sagital reversa entre os incisivos superiores e inferiores. De acordo com a evidência científica, o tratamento da MCA é indicado em casos em que a interferência oclusal favorece o crescimento mandibular em direção a um pad rão de Classe III. A ...
Source: Dental Press Journal of Orthodontics - Category: Dentistry Source Type: research
ConclusionThis case report provides evidence that a lower than previously reported dose of a phytocannabinoid in the form of a cannabidiol-based extract may be capable of aiding in autism spectrum disorder-related behavioral symptoms, core social communication abilities, and comorbid anxiety, sleep difficulties, and weight control. Further research is needed to elucidate the clinical role and underlying biological mechanisms of action of cannabidiol-based extract in patients with autism spectrum disorder.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
AbstractObjectiveTo evaluate the association between sleep duration and weight gain and incident overweight/obesity in the population of China.MethodsData were derived  from the China Health and Nutrition Survey. Adult participants with baseline data of sleep duration and body mass index (BMI) and who received at least one follow-up evaluation were selected to analyze the association of sleep duration with weight gain (n = 12,871) and incident overweight/obesity  (n = 7,752). Daily sleep duration was categorized into five groups: ≤ 6, 7, 8 (as reference), 9, and ≥ 10 h. The study out...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
This study investigated the antibacterial activities of ethyl acetate and methanol leaf-extracts of Psidium guajava (guava) and Carica papaya (paw-paw) on bacteria pathogens isolated from toothbrushes. A total of 100 manual used toothbru...
Source: Journal of Medicinal Plants Research - Category: Complementary Medicine Source Type: research
The individual antimicrobial activities of essential oils have been reported by many authors. However, there is little information about the effects of their mixtures in order to maximize their effect and reduce the growing resistance of pathogens to existing medicines. So, the aim of this work is to optimize the antibacterial and antifungal activities of essential oils from Plectranthus gla...
Source: Journal of Medicinal Plants Research - Category: Complementary Medicine Source Type: research
Publication date: Available online 21 September 2020Source: Molecular and Cellular NeuroscienceAuthor(s): A.M. Thompson, K. Farmer, E.K. Rowe, S.P. Hayley
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
Authors: MacDonald-Ramos K, Michán L, Martínez-Ibarra A, Cerbón M Abstract Silymarin is obtained from the Milk thistle plant Silybum marianum and has been used over the centuries to treat principally liver disease, although it has also been studied for its beneficial effects in cardioprotection, neuroprotection, immune modulation, and cancer among others. Importantly, silymarin's active component silybin is a flavonolignan that exhibits different activities such as; scavenger, anti-oxidant, anti-inflammatory, and recently revealed, insulin-sensitizing properties which have been explored in clin...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
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