Insight into the regulatory role of circRNA in angiogenesis and clinical implications

Angiogenesis is the physiological process of new blood vessel formation from existing capillary vessel or posterior capillary vein. Its dysfunction could result in a number of different kinds of diseases, such as cardiovascular diseases and cancer, contributing to death and disability worldwide. Circular RNAs (circRNAs) are a class of novel identified RNA molecules that have a special covalent loop structure without a 5 ′ cap and 3’ tail, which can form novel back-splicing or skipping events from precursor mRNAs.

Source: Atherosclerosis - February 24, 2020 Category: Cardiology Authors: Yan Liu, Yanyan Yang, Zhibin Wang, Xiuxiu Fu, Xian-ming Chu, Yonghong Li, Qi Wang, Xingqiang He, Min Li, Kun Wang, Jian-xun Wang, Pei-feng Li, Tao Yu Tags: Review article Source Type: research