Curative Intent Radiotherapy Delivered Within the Last Year of Life

Objectives: We studied a cohort of cancer patients that underwent curative-intent radiation within the last year of life (LYOL). Given the unexpectedly short survival, we evaluated the proportion with relapsed/refractory disease, determined causes of death, and explored whether treatment intent was associated with aggressiveness of care at the end of life. Materials and Methods: We extracted and linked claims data and radiotherapy records for patients seen at a single academic institution that died between October 1, 2014, and September 30, 2015. Results: Among 870 cancer patients, 290 were irradiated within the LYOL, of which 287 had treatment intent recorded (101 curative-intent, 186 palliative-intent). The majority of curative-intent patients had hematologic malignancies and/or underwent transplant (44.6%), followed by head and neck (9.9%) and gastrointestinal malignancies (9.9%). Half (n=49; 48.5%) had relapsed/refractory disease at the time of curative-intent radiation, including 13 with metastatic disease. Tumor progression (n=65; 64.4%) was the most common cause of death, followed by treatment-related mortality (n=27; 26.7%), of which transplant/hematologic malignancy patients (n=19) were the majority. Compared with palliative-intent patients, curative-intent patients had significantly higher rates of chemotherapy use within 14 days of death (P=0.04), intensive care unit stay within 30 days of death (P
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Health Policy Source Type: research

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Publication date: Available online 1 April 2020Source: Journal of Dental SciencesAuthor(s): Kusumawadee Utispan, Sittichai Koontongkaew
Source: Journal of Dental Sciences - Category: Dentistry Source Type: research
To the Editor We congratulate Last et al for their valuable contribution to our understanding of the risk of contralateral nodal spread in patients with human papillomavirus (HPV) –associated squamous cell carcinoma of the base of the tongue. They report occult contralateral nodal involvement in 21.4% of the cohort and appropriately argue that this warrants bilateral neck management in patients with this disease. We have 2 questions that would be relevant to the head and ne ck oncology community.
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
AbstractBackgroundSal-like protein 4 (SALL4), an embryonic stem cell factor, has been reported to play an essential role in embryogenesis and oncogenesis. As yet, however, the expression and role of this transcription factor in head and neck squamous cell carcinoma (HNSCC) has not been established.MethodsWe assessedSALL4 mRNA expression in a well-characterised dataset of 230 HNSCC samples (test cohort 110 cases and validation cohort 120 cases). We also transfected HNSCC cells (FaDu and UM-SCC-6) with SALL4 siRNA and assessed its effects on proliferation and expression of specific epigenetic factors in order to uncover the ...
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsIn this NCDB analysis, adjuvant RT was associated with decreased hazard of death for patients with localized MCC of the head and neck regardless of immune status and should be considered for both IS and IC patients.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
In this manuscript we compare the expression and applicability of biomarkers, from single genes and gene signatures, identified in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) using the GeneChip Human Transcriptome Array 2.0, nCounter and real-time polymerase chain reaction (RT-PCR) analyses. Two multicentre retrospective HNSCC patient cohorts of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG), who received postoperative radiochemotherapy (PORT-C) or primary radiochemotherapy (primary RCTx) were considered.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Source Type: research
Conditions:   Oral Cavity Cancer;   Sinonasal Cancer Interventions:   Device: Intraoral stent;   Other: No intraoral stent Sponsors:   Oslo University Hospital;   Oslo Metropolitan University Recruiting
Source: - Category: Research Source Type: clinical trials
Tuesday, March 10. Speech-language pathologist Fatima Warren was grocery shopping with her grandmother when she first noticed the painful body aches. Chalking it up to the rainy day and an earlier workout, she ran a hot bath. Wednesday, March 11. Warren woke up with chills, fever, and worsening aches. She drove straight to the closest ER in her hometown of Lexington, Kentucky. There, staff ran numerous tests, but not for COVID-19. The 45-year-old didn’t qualify because she hadn’t traveled outside the country and couldn’t name a contact with the virus. Thursday, March 12. Worried about infecting her 13-yea...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Slider Speech-Language Pathology Uncategorized acute care Cognitive Rehabilitation Dysphagia FEES Health Care MBSS personal protective equipment skilled nursing facilities Swallowing Disorders Source Type: blogs
Authors: Buzalaf MAR, Ortiz AC, Carvalho TS, Fideles SOM, Araújo TT, Moraes SM, Buzalaf NR, Reis FN Abstract Introduction: A biomarker is a biological indicator of normal or pathogenic processes. Identification of biomarkers is useful for the prevention, diagnosis and prognosis of diseases as well as for monitoring the progression of pathological disorders. Several types of molecules present in biological fluids can act as biomarkers such as DNA, coding and non-coding RNA, lipids, metabolites, proteins and even microbes. In this context, saliva emerges as a useful diagnostic tool for the detection of biomark...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
Authors: Carlson ER, Kademani D PMID: 32222170 [PubMed - in process]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Purpose of review Providing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in the form of fish oils, to benefit muscle is an emerging area of interest. The aim of this work was to evaluate the current literature that has assessed muscle mass as an outcome during a fish oil intervention in any chronic disease. Recent findings The vast majority of studies published in the last 3 years (12 of 15) have been conducted in the oncological setting, in patients undergoing treatment for cancers of the gastrointestinal tract, breast, head and neck, lung, cervix, and hematological cancers. Three studies were conducte...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: TRANSLATIONAL RESEARCH IN WASTING DISEASES: Edited by Claude Pichard and Mariëlle P.K.J. Engelen Source Type: research
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