Over-expression of Mash1 improves the GABAergic differentiation of bone marrow mesenchymal stem cells in vitro.

In conclusion, our study demonstrated that over-expression of Mash1 can improve GABAergic differentiation of BMSCs in vitro. PMID: 24144723 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research

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Authors: Cioppi F, Casamonti E, Krausz C Abstract Spermatogenesis is a highly complex biological process during which germ cells undergo recurrent rounds of DNA replication and cell division that may predispose to random mutational events. Hence, germ cells are vulnerable to the introduction of a range of de novo mutations, in particular chromosomal aberrations, point mutations and small indels. The main mechanisms through which mutations may occur during spermatogenesis are (i) errors in DNA replication, (ii) inefficient repair of non-replicative DNA damage between cell divisions and (iii) exposure to mutagens dur...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
AbstractOsteoarthritis (OA) is a common cause of chronic pain and disability. Regenerative therapies using mesenchymal stem cells (MSCs) provide an option for OA treatment as it could potentially regenerate the damaged cartilage. Bone marrow, adipose tissue and synovium are common MSC sources. The aim is to compare the therapeutic effect of MSCs from bone marrow, adipose tissue and synovium; combining its differentiation potential and accessibility, to decide the optimal source of MSCs for the treatment of knee OA. A comparison of preclinical and clinical studies using MSCs has been made with regard to treatment outcomes, ...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
ConclusionsThese results suggest that the accumulation of defects in brain microvascular endothelial cells may ultimately lead to impairment of the BBB. Small changes in barrier function over time could lead to accumulated defects that result in positive feedback to unrelated central nervous system diseases.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research
Publication date: Available online 13 July 2019Source: Journal of Neuroscience MethodsAuthor(s): Mark van den Hurk, Cedric BardyAbstractAdvances in human cell reprogramming and induced pluripotent stem cell technologies generate tremendous potential for neuroscience studies in health and disease, while the neuroscientist toolbox for engineering a range of brain tissues and neuronal cell types is rapidly expanding. Here, we discuss how the emergence of new single-cell genomics methods may help benchmarking and optimizing the tissue engineering process. The inherent heterogeneity and variability of reprogrammed brain tissue ...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
CONCLUSIONS: This study shows that ADC/CE plot can divide GBM into four regions, whose heterogeneity is evidenced by differential expression of nuclear pleomorphism, necrosis, cellularity and mitotic rate as well as the expression of oncogene and stem cell markers. PMID: 31298508 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
In conclusion, EVs of ASCs ameliorated Th2-mediated inflammation induced by Aspergillus protease antigen through the activation of dendritic cells and M2 macrophage, accompanied by down-regulation of eotaxin and IL-25, and up-regulation of TGF-β and IL-10 in mouse lung epithelial cells.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 12 July 2019Source: Stem Cell ResearchAuthor(s): Linda M. van der Graaf, Sarah L. Gardiner, Merve Tok, Tom Brands, Merel W. Boogaard, Barry A. Pepers, Bert Eussen, Annelies de Klein, N. Ahmad Aziz, Christian Freund, Ronald A.M. Buijsen, Willeke M.C. van Roon-MomAbstractHuntington disease (HD) is an autosomal dominant, neurodegenerative disease caused by a CAG repeat expansion within the coding sequence of the HTT gene, resulting in a highly toxic protein with an expanded polyglutamine stretch that forms typical protein aggregates throughout the brain. We generated human induced pluripoten...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Authors: Gugjoo MB, Fazili MR, Gayas MA, Ahmad RA, Dhama K Abstract Healing of articular cartilage is a major clinical challenge as it also lacks a direct vasculature and nerves, and carries a limited number of resident chondrocytes that do not proliferate easily. Damaged articular cartilages are usually replaced by fibrocartilages, which are mechanically and structurally weaker and less resilient. Regenerative medicine involving stem cells is considered to have a definitive potential to overcome the limitations associated with the currently available surgical methods of cartilage repair. Among various stem cell ty...
Source: Veterinary Quarterly - Category: Veterinary Research Tags: Vet Q Source Type: research
Publication date: Available online 12 July 2019Source: Journal of Molecular BiologyAuthor(s): Meret Schmidhauser, Peter F. Renz, Panagiota Tsikrika, Remo Freimann, Anton Wutz, Jeffrey L. Wrana, Tobias A. BeyerAbstractModifications by kinases are a fast and reversible mechanism to diversify the function of the targeted proteins. The OCT4 transcription factor is essential for preimplantation development and pluripotency of embryonic stem cells (ESC) and its activity is tightly regulated by post-transcriptional modifications. Several phosphorylation sites have been identified by systemic approaches and their functions propose...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 12 July 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Poushali Das, Sayan Ganguly, Priti Prasanna Maity, Hemant Kumar Srivastava, Madhuparna Bose, Santanu Dhara, Sharba Bandyopadhyay, Amit Kumar Das, Susanta Banerjee, Narayan Chandra DasAbstractProper waste utilization in order to promote value added product is a promising scientific practice in recent era. Inspiring from the recurring trend, we propose a single step oxidative pyrolysis derived fluorescent carbon dots (C-dots) from Allium sativum peel, which is a natural, nontoxic, and waste raw material. Bec...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
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