Neuroinflammation in Bipolar Depression

The objective of this review is to summarize available evidence on the connection between inflammation and BD, focusing on peripheral inflammatory markers and recent findings on their connection with other typical features of BD, to outline a general overview of the disorder. Moreover, it is meant to analyze the issues with data gathering and interpretation, given the partially contradictory and inconsistent nature of results.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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In this study, we used qPCR to quantify mtDNA copy number in 15 Holocaust survivors and 102 of their second- and third-generation descendants from the Czech Republic, many of whom suffer from PTSD, and compared them to controls in the respective generations. We found no significant difference in mtDNA copy number in the Holocaust survivors compared to controls, whether they have PTSD or not, and no significant elevation in descendants of female Holocaust survivors as compared to descendants of male survivors or controls. Our results showed no evidence of persistence or inheritance of mtDNA changes in Holocaust survivors, t...
Source: Genomics Proteomics ... - Category: Genetics & Stem Cells Authors: Tags: Front Genet Source Type: research
In this study, we aimed to evaluate the influence of insulin production on immune system after the onset of diabetes, and we showed that the duration of honeymoon period could be related to the onset of other autoimmune conditions. For this retrospective study, 159 children aged between 11 and 18 years with type 1 DM were eligible. They have been diagnosed diabetes at least 10 years ago and use exogenous insulin. Our results showed that younger age at the onset of Type 1 DM in children, predicts Celiac Disease. Female sex and low HCO3 levels at the onset of DM had a high predictive value on patients who did not experience ...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Publication date: Available online 27 March 2020Source: Brain, Behavior, and ImmunityAuthor(s): Richard T. Liu, Aislinn D. Rowan-Nash, Ana E. Sheehan, Rachel F.L. Walsh, Christina M. Sanzari, Benjamin J. Korry, Peter Belenky
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: Available online 27 March 2020Source: Brain StimulationAuthor(s): Maxim Zavorotnyy, Rebecca Zoellner, Henning Rekate, Patricia Dietsche, Miriam Bopp, Jens Sommer, Tina Meller, Axel Krug, Igor Nenadić
Source: Brain Stimulation - Category: Neurology Source Type: research
The objective was to analyze the association between psychosocial risk factors, organizational dimensions, workplace violence, and indicators of mental health problems in three Chilean hospitals. A total of 1,023 workers answered a questionnaire, and descriptive, bivariate (chi-square), and multivariate (logistic regression with odds ratio as the measure of association) analyses were performed. Of all the interviewees, 14.7% reported workplace violence. Increased odds of workplace violence were associated with exposure to ISOSTRAIN (OR = 2.32, p = 0.001), effort-reward imbalance (OR = 5.52, p ≤ 0.001), tyrannical leader...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
Publication date: Available online 28 March 2020Source: Autoimmunity ReviewsAuthor(s): Maaike Biewenga, Arantza Farina Sarasqueta, Maarten E. Tushuizen, Eveline S.M. de Jonge-Muller, Bart van Hoek, Leendert A. Trouw
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: June 2020Source: Research in Developmental Disabilities, Volume 101Author(s): Rabya Mughal, Anna Joyce, Catherine Hill, Dagmara Dimitriou
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: Available online 27 March 2020Source: Journal of Psychiatric ResearchAuthor(s): Hairong He, Chuanyu Hu, Zhenhu Ren, Ling Bai, Fan Gao, Jun Lyu
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Downregulated miR-203 attenuates IL-β, IL-6, and TNF-α activation in TRAF6-treated human renal mesangial and tubular epithelial cells. Int J Clin Exp Pathol. 2020;13(2):324-331 Authors: Zhang L, Zhang X Abstract Circulating microRNAs (miRNAs) are attracting major interest as novel non-invasive biomarkers for human autoimmune diseases including lupus nephritis (LN). A previous study showed that altered miR-203 expression may provide highly diagnostic for systemic lupus erythematosus. However, whether miR-203 is a diagnostic biomarker for LN is still unknown. In the present research, serum sa...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
Abstract Down's syndrome (DS; also known as trisomy 21; T21) is caused by a triplication of all or part of human chromosome 21 (chr21). DS is the most common genetic cause of intellectual disability attributable to a naturally-occurring imbalance in gene dosage. DS incurs huge medical, healthcare, and socioeconomic costs, and there are as yet no effective treatments for this incapacitating human neurogenetic disorder. There is a remarkably wide variability in the 'phenotypic spectrum' associated with DS; the progression of symptoms and the age of DS onset fluctuate, and there is further variability in the biophysi...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
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