Progressive supranuclear palsy and primary lateral sclerosis secondary to globular glial tauopathy: a case report and a practical theoretical framework for the clinical prediction of this rare pathological entity.

We report the case of a patient with eye-movement abnormalities and gait instability, reminiscent of progressive supranuclear palsy-Richardson's syndrome (PSP-RS), who later developed upper motor neuron symptoms suggestive of primary lateral sclerosis (PLS). Neuropathological assessment revealed GGT type III pathology. A theoretical framework is proposed to help clinicians predict GGT in subjects with coexistent features of PSP-RS and PLS.
PMID: 32090696 [PubMed - as supplied by publisher]

Source: Neurocase - February 22, 2020 Category: Neurology Authors: Liu AJ, Chang JE, Naasan G, Boxer AL, Miller BL, Spina S Tags: Neurocase Source Type: research