Intranasal Immunization Using CTA1-DD as a Mucosal Adjuvant for an Inactivated Influenza Vaccine

Publication date: July 2019Source: Biomedical and Environmental Sciences, Volume 32, Issue 7Author(s): Xue Ting FAN, Yun Long WANG, Qiu Dong SU, Feng QIU, Yao YI, Zhi Yuan JIA, Da Yan WANG, Kun QIN, Ye Ning ZOU, Sheng Li BI, Li Ping SHEN
Source: Biomedical and Environmental Sciences - Category: Biomedical Science Source Type: research

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This report highlights some of the knowledge shared at the SPSASV.
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - Category: Tropical Medicine Source Type: research
Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using computational tools. Tools that facilitate the in silico prediction of immune response to biothreats, emerging infectious diseases, and cancers can accelerate the design of novel and next generation vaccines and their delivery to the clinic. Over the past 20 years, vaccinologists, bioinformatics experts, and advanced programmers based in Providence, Rhode Island, USA have advanced the development of an integrated toolkit for vaccine design called iVAX, that is secure and user-accessible by internet. This integrated set of immu...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
One would hope that it does not require an ongoing pandemic and related hysteria to point out that old people have poorly functioning immune systems, and thus suffer disproportionately the burden of infectious disease. But perhaps it does. The 2017-2018 seasonal influenza, a modestly more severe occurrence of something that happens every year, killed something like 60,000 people in the US alone, with little notice or comment. There is nothing so terrible that it won't be accepted - ignored, even - if it is normal. Floodgates of funding for infectious disease research and development have been opened in response to C...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
ConclusionsDue to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
uijandria JM, Azziz-Baumgartner E, Thompson MG, VIP Cohort Study Working Group Abstract BACKGROUND: The Estudio Vacuna de Influenza Peru (VIP) cohort aims to describe the frequency of influenza virus infection, identify predictors of vaccine acceptance, examine the effects of repeated influenza vaccination on immunogenicity, and evaluate influenza vaccine effectiveness among HCP. METHODS: The VIP cohort prospectively followed HCP in Lima, Peru, during the 2016-2018 influenza seasons; a fourth year is ongoing. Participants contribute blood samples before and after the influenza season and after influenza vacci...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Influenza Other Respir Viruses Source Type: research
Authors: Valentino S, Suit L Abstract Background: The community college student is not currently armed with the resources or prevention information regarding influenza. Less than twenty percent of the college population receives influenza immunization annually.Purpose: The purpose of the project was to evaluate if an evidenced-based influenza and vaccine education intervention will affect nursing students' intent to vaccinate for influenza by increasing knowledge of the influenza vaccine using Zingg and Siegrist's Knowledge Scale.Methods: Participants were recruited voluntarily from their attendance at orientation ...
Source: Journal of Community Health Nursing - Category: Nursing Tags: J Community Health Nurs Source Type: research
AbstractThe use of the nanocapsulated adjuvant Sapomax increased the expression of innate immunity genes (H2Q10, Ddx58, Tyk2, Tlr3, Tlr7, and TNF) responsible for the primary recognition of influenza virus, i.e., those belonging to the RLR and TLR families; genes involved in stimulating the production of type I and III IFN and pro-inflammatory cytokines; and Th1 and Th2 cellular immunity genes (Ccr4, Ccr5, IFN γ, IL-2, IL-4, and IL-10) responsible for triggering regulatory immune mechanisms in the cell. The high immunological activity of the plant-derived nanocapsulated adjuvant Sapomax may be used to enhance the efficacy of vaccines.
Source: Archives of Virology - Category: Virology Source Type: research
The reassortant vaccine strain of live attenuated influenza vaccine inherits temperature sensitivity and areactogenicity from cold-adapted attenuated master donor virus. In Russia, B/ USSR/60/69 master donor virus (B60) is currently in use for the preparation of live attenuated type B influenza vaccine candidates. Trivalent live attenuated influenza vaccine based on A/ Leningrad/134/17/57 and B60 are licensed for the use in Russia for single dose vaccination of adults and children over 3 years. B/Leningrad/14/17/55 (B14) cold-adapted virus is a backup master donor virus for live attenuated type B influenza vaccine. Accordi...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
Authors: Schlipköter U, Flahault A Abstract The past two centuries have seen enormous achievements in control of infectious diseases, previously the leading cause of death, in large measure due to sanitation and food safety, vaccines, antibiotics and improved nutrition. This has led people to put their faith in the notion that medical science would succeed in overcoming the remaining obstacles. Vaccination has eradicated smallpox, nearly eradicated poliomyelitis and greatly reduced many other highly dangerous infections such as diphtheria, tetanus and measles. New diseases such as HIV and new forms of influenz...
Source: Public Health Reviews - Category: International Medicine & Public Health Tags: Public Health Rev Source Type: research
The risks, so far, seem no greater than for anyone else, but the research is thin and only applies to later stage of pregnancy.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Women and Girls Pregnancy and Childbirth Coronavirus (2019-nCoV) Babies and Infants Quarantines Epidemics Swine Influenza Vaccination and Immunization SARS (Severe Acute Respiratory Syndrome) Breastfeeding American College of Obstetric Source Type: news
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