Molecules, Vol. 25, Pages 1025: Trastuzumab Conjugated Superparamagnetic Iron Oxide Nanoparticles Labeled with 225Ac as a Perspective Tool for Combined α-Radioimmunotherapy and Magnetic Hyperthermia of HER2-Positive Breast Cancer
Molecules, Vol. 25, Pages 1025: Trastuzumab Conjugated Superparamagnetic Iron Oxide Nanoparticles Labeled with 225Ac as a Perspective Tool for Combined α-Radioimmunotherapy and Magnetic Hyperthermia of HER2-Positive Breast Cancer
Molecules doi: 10.3390/molecules25051025
Authors:
Edyta Cędrowska
Marek Pruszyński
Weronika Gawęda
Michał Żuk
Paweł Krysiński
Frank Bruchertseifer
Alfred Morgenstern
Maria-Argyro Karageorgou
Penelope Bouziotis
Aleksander Bilewicz
It has been proven and confirmed in numerous repeated tests, that the use of a combination of several therapeutic methods gives much better treatment results than in the case of separate therapies. Particularly promising is the combination of ionizing radiation and magnetic hyperthermia in one drug. To achieve this objective, magnetite nanoparticles have been modified in their core with α emitter 225Ac, in an amount affecting only slightly their magnetic properties. By 3-phosphonopropionic acid (CEPA) linker nanoparticles were conjugated covalently with trastuzumab (Herceptin®), a monoclonal antibody that recognizes ovarian and breast cancer cells overexpressing the HER2 receptors. The synthesized bioconjugates were characterized by transmission electron microscopy (TEM), Dynamic Light Scattering (DLS) measurement, thermogravimetric analysis (TGA) and application of 131I-labeled trastuzumab for quantification of the bound biomolecule. The obtained results show that ...
Source: Molecules - Category: Chemistry Authors: Edyta C ędrowska Marek Pruszy ński Weronika Gaw ęda Micha ł Żuk Pawe ł Krysiński Frank Bruchertseifer Alfred Morgenstern Maria-Argyro Karageorgou Penelope Bouziotis Aleksander Bilewicz Tags: Article Source Type: research
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