Bacterial Resistance: antibiotics of last generation used in clinical practice and the arise of natural products as new therapeutic alternatives.

Bacterial Resistance: antibiotics of last generation used in clinical practice and the arise of natural products as new therapeutic alternatives. Curr Pharm Des. 2020 Feb 23;: Authors: Corrêa RCG, Heleno SA, Alves MJ, Ferreira ICFR Abstract Bacterial resistance to the therapeutical drugs has been a serious issue over the last decades. In fact, the quick development of resistance mechanisms by the microorganisms has been fatal for millions of people around the world, turning into a public health issue. The major cause for the resistance mechanisms is the overuse of antimicrobials. European countries try to implement mechanisms to overcome antimicrobial resistance in the community through the rational use of antimicrobials. The scientific community has been exhaustively dedicated to the discovering of new, safer and efficient drugs, being the exploitation of natural resources, mainly plants and fungi, considered as a hot topic in the field of antimicrobial agents. Innumerous reports have already shown the promising capacity of natural products or molecules extracted from these natural resources, to act as bacteriostatic and bactericidal agents. More importantly, these natural agents present significantly lower harmful effects. Bearing that in mind, this review aims at giving a contribution to the knowledge about the synthetic antibiotics of last generation. Moreover, it is intended to provide information about the last advances regard...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research