Targeting G protein-coupled receptors in cancer therapy.

Targeting G protein-coupled receptors in cancer therapy. Adv Cancer Res. 2020;145:49-97 Authors: Soond SM, Zamyatnin AA Abstract As basic research into GPCR signaling and its association with disease has come into fruition, greater clarity has emerged with regards to how these receptors may be amenable to therapeutic intervention. As a diverse group of receptor proteins, which regulate a variety of intracellular signaling pathways, research in this area has been slow to yield tangible therapeutic agents for the treatment of a number of diseases including cancer. However, recently such research has gained momentum based on a series of studies that have sought to define GPCR proteins dynamics through the elucidation of their crystal structures. In this chapter, we define the approaches that have been adopted in developing better therapeutics directed against the specific parts of the receptor proteins, such as the extracellular and the intracellular domains, including the ligands and auxiliary proteins that bind them. Finally, we also briefly outline how GPCR-derived signaling transduction pathways hold great potential as additional targets. PMID: 32089165 [PubMed - in process]
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research

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The transcription factor β-catenin is able to induce tolerogenic/anti-inflammatory features in different types of dendritic cells (DCs). Monocyte-derived dendritic cells (moDCs) have been widely used in dendritic cell-based cancer therapy, but so far with limited clinical efficacy. We wanted to investigate the hypothesis that aberrant differentiation or induction of dual pro- and anti-inflammatory features may be β-catenin dependent in moDCs. β-catenin was detectable in both immature and lipopolysaccharide (LPS)-stimulated DCs. The β-catenin inhibitor ICG-001 dose-dependently increased the pro-inflammat...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In conclusion, these data demonstrated that polydatin induced MG-63 cell death through inducing apoptosis, and autophagy which was mediated via the STAT3 signaling. Therefore, polydatin might be a potential clinical drug in the remedy of osteosarcoma.Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research
Functional metal ‐containing polydopamine nanomaterials with metal/metal ions as the active functions are reviewed, including their synthesis and metal coordination environment and their applications in catalysis, batteries, solar cells, capacitors, bioimaging, therapy, antifouling, and antibacterial coating. The current trends, limitations, and future directions of this area are also discussed. AbstractPolydopamine (PDA) is a major type of artificial melanin material with many interesting properties such as antioxidant activity, free ‐radical scavenging, high photothermal conversion efficiency, and strong metal‐ion ...
Source: Small - Category: Nanotechnology Authors: Tags: Review Source Type: research
This study aimed to investigate whether a combined treatment of dl355 and Cis-diamminedichloroplatinum (CDDP) can have a synergistic cell-killing effect on cancer cells. We confirmed the effect of CDDP in nucleocytoplasmic HuR shuttling. In vitro and in vivo experiments showed the enhancement of cancer cell death by apoptosis induction and a significant reduction in tumor growth following combination treatment. These results suggested that combination therapy exerted a synergistic antitumor activity by upregulation of CDDP induced cytoplasmic HuR, which led to ARE mRNA stabilization and increased virus proliferation. Besid...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
verdlov The failure of therapies directed at targets within cancer cells highlight the necessity for a paradigm change in cancer therapy. The attention of researchers has shifted towards the disruption of cancer cell interactions with the tumor microenvironment. A typical example of such a disruption is the immune checkpoint cancer therapy that disrupts interactions between the immune and the cancer cells. The interaction of cancer antigens with T cells occurs in the immunological synapses. This is characterized by several special features, i.e., the proximity of the immune cells and their target cells, strong intercel...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Authors: Goldenberg DM, Cardillo TM, Govindan SV, Rossi EA, Sharkey RM Abstract [This corrects the article DOI: 10.18632/oncotarget.4318.]. PMID: 32206190 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
We present a method involving oxidative functionalization followed by a solvothermal cutting technique for the synthesis of strong-blue-emitting GQD nanomaterial in cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Nature Reviews Cardiology, Published online: 26 March 2020; doi:10.1038/s41569-020-0347-2This Review outlines the mechanisms of cancer therapy-related vascular toxicity and provides recommendations for screening, treatment and prevention in the context of available evidence and society guidelines. The Review focuses on the main types of arterial toxicity, acute vasospasm, acute thrombosis and accelerated atherosclerosis, and provides an update on cancer therapy-related venous thromboembolism and pulmonary hypertension.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research
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Publication date: June 2020Source: Materials Science and Engineering: C, Volume 111Author(s): Kunal Pal, Shubham Roy, Pravat Kumar Parida, Ananya Dutta, Souravi Bardhan, Sukhen Das, Kuladip Jana, Parimal Karmakar
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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