Influence of Hormone Treatment in Radiation Therapy for Bladder Cancer

Conditions:   Bladder Cancer;   Radiation Therapy Complication;   Quality of Life Intervention:   Drug: Degarelix Sponsor:   Aarhus University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Publication date: Available online 26 February 2020Source: Practical Radiation OncologyAuthor(s): Kimberly R. Gergelis, Cole R. Kreofsky, Christopher S. Choo, Jason Viehman, W. Scott Harmsen, Scott C. Lester, Thomas M. Pisansky, Brian J. Davis, Bradley J. Stish, Richard Choo
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Radiation cystitis, a severely debilitating condition characterized by fibrosis, vascular damage, and compromised bladder function, develops in cancer survivors who received pelvic radiation treatment. This is the first study to compare the effects of radiation on the bladder across different murine genetic backgrounds, which may explain differences in patients ’ sensitivity to developing radiation cystitis after radiation cancer treatment. AbstractA subset of patients receiving radiation therapy for pelvic cancer develop radiation cystitis, a complication characterized by mucosal cell death, inflammation, hematuria,...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
AbstractTrimodality bladder preservation (BP) is an accepted alternative to radical cystectomy for patients with muscle invasive bladder cancer (MIBC). The global utilization of BP is variable, and practice patterns have not been previously studied in Russia. We sought to elucidate the contemporary BP practice patterns in Russia and determine the impact of the BP workshop on attitudes of Russian radiation oncologists (ROs) towards BP. The workshop was focused on patient workup, selection for BP, chemotherapy choices, radiation therapy (RT) contouring and planning, patient counseling. A total of 77 pre- and 32 matched post-...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
Radiation cystitis, a severely debilitating condition characterized by fibrosis, vascular damage, and compromised bladder function, develops in cancer survivors who received pelvic radiation treatment. This is the first study to compare the effects of radiation on the bladder across different murine genetic backgrounds, which may explain differences in patients ’ sensitivity to developing radiation cystitis after radiation cancer treatment. AbstractA subset of patients receiving radiation therapy for pelvic cancer develop radiation cystitis, a complication characterized by mucosal cell death, inflammation, hematuria,...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Conditions:   Bladder Cancer;   Radiation Therapy Complication;   Quality of Life Intervention:   Drug: Degarelix Sponsor:   Aarhus University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions This review highlights the breadth of strategies that aim to preserve a patient ’ s bladder while still optimizing local tumor control and overall survival. Future areas for innovation include the use of predictive biomarkers and implementation of immunotherapy, moving the field towards patient-tailored care.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: CCIC is an effective means of treating refractory bladder neck contractures and/or urinary incontinence. While morbidity rates are high, subjective patient satisfaction is high. PMID: 32065865 [PubMed - in process]
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
AbstractObjectiveIntensity-modulated radiation therapy (IMRT) using a volumetric-modulated arc therapy technique may offer dosimetric and clinical benefits compared to the historical standard of care 3D conformal radiotherapy (3D-CRT) in definitive treatment of bladder cancer. We hypothesized that IMRT with CBCT would reduce dose to the rectum, bowel, and bladder compared to 3D-CRT.MethodsWe reviewed nineteen patients treated with maximal transurethral resection of bladder tumor followed by concurrent chemotherapy with IMRT. All patients received 45  Gy to the entire empty bladder followed by 19.8 Gy tumor boost ...
Source: Journal of Radiation Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsCystoscopy-guided placement of hydrogel markers is both safe and feasible for muscle-invasive bladder tumors. Adequate performance for radiation purposes throughout the whole course (implantation, delineation, and positional verification) was 46.7% of all implanted markers, leaving room for improvement.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: Our findings suggest that IMRT may represent a viable alternative in delivering the boost in patients diagnosed with gynaecological cancer not amenable to ICBRT. PMID: 32010217 [PubMed]
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
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