Denver's move to allow cannabis research opens the door for Alzheimer's study
One Denver cannabis company says it's ready to move forward with dementia studies as soon as City Council approves a proposed ordinance.
AbstractAlzheimer ’s disease (AD) is a neurodegenerative disease, known as the most common form of dementia. In AD onset, abnormal rRNA expression has been reported to be linked in pathogenesis. Although region-specific expression patterns have previously been reported in AD, it is not until recently that the cereb ellum has come under the spotlight. Specifically, it is unclear whether DNA methylation is the mechanism involved in rRNA expression regulation in AD. Hence, we sought to explore the rDNA methylation pattern of two different brain regions – auditory cortex and cerebellum – from AD and age-/sex-...
ConclusionMultimodal analysis conducted with various image data from PiB-PET/MRI scans showed differences in regional CBF, cortical volume, and neuronal networks in different regions, indicating that pathophysiologic and functional changes in the AD brain can be observed from various aspects of neurophysiologic parameters. Application of multimodal brain images using PET/MRI would be ideal for investigating pathophysiologic changes in patients with dementia and other neurodegenerative diseases.
CONCLUSIONS: WM pathology is strongly associated with impaired processing speed, and our results indicate that these impairments arise from WMH in the temporal and parieto-occipital regions. In MCI and AD patients with temporal WMH, processing speed impairments are especially prominent. The results of this study increase our knowledge of cognitive repercussions stemming from temporal and/or parieto-occipital WM pathology in healthy and pathological aging. PMID: 32209796 [PubMed - as supplied by publisher]
Daily low-dose aspirin as prevention therapy takes another hit, this time for not reducing risk of Alzheimer's disease or cognitive impairment in a large randomized study.Medscape Medical News
Older men and women who took low-dose aspirin did not show improvements in memory or a lower risk of dementia.
Conclusions: In this study, we observed in middle- and old-aged individuals with neither dementia nor alcohol-related disorders that moderate lifetime alcohol intake was associated with lower cerebral AB deposition compared to a lifetime history of not drinking. Moderate lifetime alcohol intake may have a beneficial influence on AD by reducing pathological amyloid deposition rather than amyloid-independent neurodegeneration or cerebrovascular injury. The Study in Context: Report: 35% of worldwide dementia cases could be prevented by modifying these 9 modifiable risk factors Study: Drinking up to 5–8 glasses of wine...
IJERPH, Vol. 17, Pages 2261: Intention to Screen for Alzheimer’s Disease by Residential Locale International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072261 Authors: Lilah M. Besser Willa D. Brenowitz Juyoung Park Magdalena I. Tolea James E. Galvin A random digit dialing sample from Missouri (USA) was used to compare associations between psychosocial factors and Alzheimer’s disease (AD) screening intention based on residential locale. Linear regression associations between demographics and five psychosocial constructs (dementia knowledge, perceived screening b...
As the population ages, the incidence of chronic diseases such as dementia increases. Dementia with Lewy bodies (DLB) is one of the most common dementias after Alzheimer's Disease (AD), and it is characterized clinically by a tetrad consisting of visual hallucinations, spontaneous parkinsonism, REM sleep behavior disorders and dementia . The diagnosis of DLB is challenging. Despite the validated diagnostic criteria, only one in three cases is correctly identified. These criteria have a low sensitivity of 32%, while its specificity has been reported in 95% when its diagnostic accuracy is compared to autopsy .
Publication date: Available online 25 March 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Ming-Jang Chiu, Ta-Fu Chen, Chaur-Jong Hu, Sui-Hing Yan, Yu Sun, Bing-Hsien Liu, Yun-Tsui Chang, Che-Chuan Yang, Shieh-Yueh Yang
Disruptions in routines and the need for hands-on care are among the special challenges for dementia patients and their caregivers.