Another coronavirus, another epidemic, another warning.

Another coronavirus, another epidemic, another warning. Vaccine. 2020 Feb 28;38(10):v-vi Authors: Poland GA PMID: 32089242 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

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AbstractRecently, various studies have shown that angiotensin-converting enzyme 2 (ACE2) acts as the “doorknob” that can be bound by the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which conduces to its entrance to the host cells, and plays an important role in corona virus disease 2019 (COVID-19). This paper aims to collect and sorts out the existing drugs, w hich exert the ability to block the binding of S protein and ACE2 so as to provide directions for the later drug development. By reviewing the existing literature, we expound the pathogenesis of SARS-CoV-2 from the persp...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
While the world awaits a proven COVID-19 vaccine, medical experts are turning their attention to a shot that’s long been a key component in the public health toolbox: the flu vaccine. Experts hope this year’s flu shot can help prevent an influenza epidemic paired with another wave of coronavirus, which could overwhelm hospitals and lead to general confusion, given that it can be difficult to tell a COVID-19 infection from a case of the flu. This flu season is also something of a dress rehearsal for the eventual rollout of a COVID-19 vaccine amid the ongoing pandemic, allowing doctors, nurses and pharmacists a c...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Purpose of review To discuss the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by nucleic acid and antibody testing as well as its contribution to mitigating the spread of coronavirus disease 2019. Recent findings Nucleic acid testing (NAT) is the firstly developed and most widely used diagnostic technique for SARS-CoV-2 infection. However, the sensitivity of SARS-CoV-2 RNA NAT assays is always unsatisfactory, mainly due to insufficient viral RNA in samples, especially when upper respiratory samples were used. Compared with NAT assays, serological tests are more convenient and les...
Source: Current Opinion in HIV and AIDS - Category: Infectious Diseases Tags: COVID19: Edited by Zhiwei Chen and Linqui Zhang Source Type: research
The COVID-19 pandemic has had a worldwide effect for what seems like an eternity. After shelter-in-place orders became more prevalent in March,  most people probably didn’t think they’d still be wearing masks in October. So the question remains, when will the pandemic end?  It turns out there are quite a few factors that contribute to the rise and fall of a pandemic, some within our control, some that are not. An outbreak becomes a pandemic when it meets two criteria, first, it spreads rapidly and widely, and second, it must qualify as a severe disease. If either of these factors change, it is no long...
Source: Conversations with Dr Greene - Category: Child Development Authors: Tags: Dr. Greene's Blog Coronavirus COVID COVID-19 COVID-19 Feature Source Type: blogs
There are few things as powerful as avoidance learning. Touch a hot stove once and you’re not likely to do it again. Cross against the light and almost get hit by a car and you’re going to be a lot more careful the next time. But when it comes to the U.S. response to COVID-19? Not so much. You’d have thought that the sight of overflow hospital tents and refrigerated trucks to hold victims’ bodies in New York would have been enough to scare us all straight in mid-March and early April, when infection rates peaked at 32,000 new cases a day, or nearly 10 cases per 100,000 residents—making social ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 UnitedWeRise20Disaster Source Type: news
Jeffrey A. SingerSome observers of our policy toward the coronavirus pandemiccriticize the tendency to focus on case numbers alone, when hospitalization rates and fatality rates are what really matter. And as we learn more about the COVID virus, mitigation and treatment is improving and fatalities are diminishing.Similarly, the U.S. Department of Justice ’s policy toward the overdose epidemic seems to be focused on arrests and drug interdictions, apparent in a DOJpress release today, itemizing the arrests of drug traffickers and seizures of illegal drugs that have resulted since “Operation SOS&rd...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
We present advances in modeling techniques that have led to fundamental disease discoveries and impacted clinical translation.Recent FindingsCombining mechanistic models and machine learning algorithms has led to improvements in the treatment ofShigella and tuberculosis through the development of novel compounds. Modeling of the epidemic dynamics of malaria at the within-host and between-host level has afforded the development of more effective vaccination and antimalarial therapies. Similarly, in-host and host-host models have supported the development of new HIV treatment modalities and an improved understanding of the i...
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research
AbstractPurpose of ReviewCoronavirus disease 2019 (COVID-19) pandemic has major health and economic impacts. We review disease characteristics in children.Recent FindingsChildren comprise 1 –2% of the diagnosed cases, and typically suffer mild disease. The median age of infected children is 3.3–11 years, and male/female ratio is 1.15–1.55. Common symptoms in children include upper respiratory symptoms (26–54%), cough (44–54%), fever (32–65%), and gastrointestinal (15–30% ) symptoms. Substantial proportion (4–23%) are asymptomatic. Death rates are up to 0.7%. Risk factors...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
i-Long Chen Some coronaviruses are zoonotic viruses of human and veterinary medical importance. The novel coronavirus, severe acute respiratory symptoms coronavirus 2 (SARS-CoV-2), associated with the current global pandemic, is characterized by pneumonia, lymphopenia, and a cytokine storm in humans that has caused catastrophic impacts on public health worldwide. Coronaviruses are known for their ability to evade innate immune surveillance exerted by the host during the early phase of infection. It is important to comprehensively investigate the interaction between highly pathogenic coronaviruses and their hosts. In th...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Coronavirus disease 2019 (COVID-19), an acute onset pneumonia caused by a novel Betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in the Wuhan City of China in December 2019 and evolved into a global pandemic. To date, there are no proven drugs or vaccines against this virus. Hence, the situation demands an urgent need to explore all potential therapeutic strategies that can be made available to prevent the disease progression and improve patient outcomes. In absence of clinically proven treatment guidelines, several repurposed drugs and investigational agents are currently being evalua...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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