Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures

Publication date: April 2020Source: Epilepsy &Behavior, Volume 105Author(s): Mariana de Souza Aranha Garcia-Gomes, Dennis Albert Zanatto, Orfa Yineth Galvis-Alonso, Jorge Mejia, Ana Tada Fonseca Brasil Antiorio, Pedro Kenzo Yamamoto, Márcia Carolina Millán Olivato, Thaísa Meira Sandini, Jorge Camilo Flório, Ivo Lebrun, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro, Maria Martha Bernardi, Susan Ienne, Tiago Antonio de Souza, Maria Lúcia Zaidan Dagli, Claudia Madalena Cabrera Mori
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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Publication date: Available online 1 April 2020Source: Epilepsy &BehaviorAuthor(s): Alain Braillon
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
OBJECTIVE: Posttraumatic epilepsy (PTE) is a well-described complication of traumatic brain injury (TBI). The majority of the available data regarding PTE stem from the adult population. Our aim was to identify the clinical and radiological risk factors as...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
(Novela Neurotech) A collaboration between Novela Neurotech and NeuroTechX launches a month-long challenge with cash prize for everyone working from home. The challenge aims to harness a new generation of AI and online big data resources to develop better seizure prediction algorithms using scalp EEG signals. Winning solutions will be made available online and open-sourced to encourage further improvements.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
We report a 7-year-old boy with this syndrome whose refractory and behavioral abnormalities have been remarkably improved by treatment with LCM.
Source: Brain and Development - Category: Neurology Authors: Tags: Case Report Source Type: research
A variety of neuropeptides play important roles as neurotransmitters or neurotransmitter modifiers in the brain, and may be involved in the incidence and development of epilepsy. In recent years, the following neuropeptides: galanin (GAL), neuropeptide Y (NPY), neuropeptide substance P (SP), cholecystokinin (CCK), as well as wake-promoting neuropeptide (ORE) have been discovered to be closely associated with epilepsy. Vagus nerve stimulation (VNS) is an effective therapy for patients with drug-resistant epilepsy [1].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
The abnormal allocation of nodules of grey matter in areas of the brain or spinal cord that should physiologically be occupied by white matter characterizes a neural defect called Grey Matter Heterotopia (GMH). The improvement of MRI techniques has enabled a deeper understanding of the neuropathological bases and epidemiology of such a condition. Among its major manifestations, there is the onset of epileptic seizures, mild intellectual disability, impairments in executive functioning, neurodevelopmental disorders; less frequently GMH has been found associated with depression, anxiety, and schizophrenia. Despite the clinic...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Testicular torsion is a common urologic emergency and one of the causes of genital injury in males. Hence, early diagnosis and treatment are necessary to prevent testicular damage and infertility. It has been proved that topiramate (TPM) a medication used to treat epilepsy and prevent migraines has anti-inflammatory and anti-oxidative effects. Therefore, this study was designed to determine the influence of TPM on ischemia/reperfusion injury following testicular torsion/detorsion (T/D). Thirty-six male Wistar rats were divided into three groups (n  = 12 for each group) including sham operated, T/D + vehicle, T/D ...
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
AbstractValproate is a broad-spectrum antiepileptic drug (AED) of particular interest in pediatric epilepsy syndromes and idiopathic generalized epilepsy, as it is relatively more effective in these syndromes than other AEDs. In 2018, the European Medicines Agency introduced new restrictions on the use of valproate in girls and women of childbearing potential to avoid exposure during pregnancy. The strengthening of existing restrictions sparked controversy and debate among patients and the medical community. The high prevalence of epilepsy syndromes amenable to valproate treatment in women of childbearing age and the littl...
Source: Journal of Neurology - Category: Neurology Source Type: research
This article highlights the benefits that pediatric MEG has to offer to clinical practice and pediatric research, particularly for infants and young children; reviews the existing literature on adult MEG systems for pediatric use; briefly describes the few pediatric MEG systems currently extant; and draws attention to future directions of research, with focus on the clinical use of MEG for patients with drug-resistant epilepsy.
Source: Neuroimaging Clinics - Category: Radiology Authors: Source Type: research
The technology, tested out on patients with epilepsy who already had electrodes implanted in their brains, is currently limited to 30 –50 sentences.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
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