High Flow Nasal Therapy Use in Patients with Acute Exacerbation of COPD and Bronchiectasis: A Feasibility Study.

High Flow Nasal Therapy Use in Patients with Acute Exacerbation of COPD and Bronchiectasis: A Feasibility Study. COPD. 2020 Feb 24;:1-7 Authors: Crimi C, Noto A, Cortegiani A, Campisi R, Heffler E, Gregoretti C, Crimi N Abstract The efficacy and feasibility of high flow nasal therapy (HFNT) use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and bronchiectasis is unknown. We performed a single-center, single-arm prospective observational study in patients with AECOPD, documented bronchiectasis, pH ≥ 7.35, respiratory rate (RR) ≥ 26 breaths/minute despite receiving maximal medical treatment and oxygen via face mask up to 10 L/m. Patients received HFNT (Airvo 2, Fisher &Paykel) at a gas flow of 50 L/min and FIO2 adjusted to maintain SpO2 ≥92%. Dyspnea, rated by Borg scale, RR, arterial blood gases and mucus production (ranging from 1 to 3) were collected before and 1 h after starting HFNT and then every 24 h for 3 days. Tolerance was measured using a visual analogic scale (VAS). Fifteen patients were enrolled. After 24 h, patients showed a significant improvement in dyspnea score [Borg scale from 6.7 ± 1.4 to 4.1 ± 1.3 (p
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research

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Publication date: Available online 27 March 2020Source: Respiratory Medicine Case ReportsAuthor(s): Christopher Oleynick
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
CONCLUSIONS: TERT rs2736100 was associated with the risks of both IPF and COPD in a Japanese population. A combination of the "at-risk" genotypes might be important to identify the population at risk for IPF more clearly. PMID: 32212792 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
AbstractPurposeTo investigate risk factors for severe bleeding during warfarin treatment, including the influence of sex, age, comorbidity and co-medication on bleeding risk.MethodsPatients initiating warfarin treatment between 2007 and 2011 were identified in the nationwide Swedish Prescribed Drug Register, and diagnoses of severe bleeding were retrieved from the National Patient Register. Hazard ratios (HR) with 95% confidence intervals (CI) for severe bleeding were estimated using multiple Cox regression adjusting for indications and including covariates age, sex, comorbidities and co-medications. Interactions between s...
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
If you ’re one of millions of Americans exposed to air pollution, you may be at a greater risk of catching the coronavirus — and of having a more severe infection.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) Air Pollution Respiratory Diseases Asthma Chronic Obstructive Pulmonary Disease Global Warming Environment Source Type: news
(Natural News) Chronic respiratory conditions can significantly affect an individual’s quality of life. From breathlessness to chronic chest pain, respiratory conditions cause a host of complications that can impair the flow of oxygen throughout the body. For instance, chronic obstructive pulmonary disease (COPD), an incurable lung disease, can make it difficult for an individual to...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conditions:   Virus Diseases;   Infection Viral Interventions:   Drug: Azithromycin;   Drug: Hydroxychloroquine;   Drug: Placebo oral tablet Sponsor:   Chronic Obstructive Pulmonary Disease Trial Network, Denmark Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsThe 85% of enrolled patients showed poor adherence to free triple inhaled therapy. Co ‐morbidities, such as heart failure (OR 1.78, 95%CI 1.19‐2.75), depression (OR 1.41, 95%CI 1.06‐1.88), and peripheral vascular disease (OR 1.32, 95%CI 1.01‐1.74) were associated with poor adherence. Former (OR 0.52, 95%CI 0.34‐0.78) or current smokers (OR 0.61, 95%CI 0.41‐0.93) and patie nts with more severe airways obstruction or history of severe exacerbations (OR 0.64, 95%CI 0.52‐0.79) were less likely to exhibit poor adherence. Real‐world adherence to triple inhaled therapy with different inhalers is general...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
Pulsus paradoxus – MCQ – Answer Pulsus paradoxus represents – Correct answer: a) Exaggerated inspiratory fall in blood pressure Normally there is an inspiratory fall in blood pressure of less than 10 mm Hg. This fall is exaggerated in pulsus paradoxus and can be noted in cardiac tamponade and severe obstructive pulmonary disease. In cardiac tamponade,  right heart compression prevents inspiratory increase in flow to the right heart and exaggerates the usual drop in venous return to the left heart resulting in fall of blood pressure. In chronic obstructive pulmonary disease, the swings in venous retur...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs
PMID: 32212973 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
The underlying pathophysiological determinants of asthma and COPD are related in complex ways. Importantly however, post-bronchodilator forced expiratory volume in 1 s (FEV1) reversibility may occur in approximately 50% of COPD patients [1], whilst epidemiological [2] and magnetic resonance imaging (MRI) studies [3] suggest that, in asthma patients, FEV1 reversibility may diminish over time. As compared to patients with asthma or COPD alone, patients with co-existing asthma and COPD report worse clinical outcomes [4] and increased healthcare costs [5] and burden [4, 5].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
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