Optimising epilepsy management with a smartphone application: a randomised controlled trial.

Optimising epilepsy management with a smartphone application: a randomised controlled trial. Med J Aust. 2020 Feb 24;: Authors: Si Y, Xiao X, Xia C, Guo J, Hao Q, Mo Q, Niu Y, Sun H Abstract OBJECTIVE: To assess whether a practical intervention based upon a smartphone application (app) would improve self-management and seizure control in adults with epilepsy. DESIGN, SETTING: Randomised, controlled trial in western China, December 2017 to August 2018. PARTICIPANTS: 380 eligible people with epilepsy were recruited; 327 completed the 6-month follow-up (176 in the app group, 151 in the control group). MAIN OUTCOME MEASURES: Self-management of epilepsy (measured with the validated Chinese Epilepsy Self-Management Scale, C-ESMS) and self-reported seizure frequency. RESULTS: In the intention-to-treat analysis, the mean C-ESMS score increased significantly in the app group between baseline and the 6-month evaluation (from 121.7 [SD, 12.1] to 144.4 [SD, 10.0]; P 
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research

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The technology, tested out on patients with epilepsy who already had electrodes implanted in their brains, is currently limited to 30 –50 sentences.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
Authors: Uysal SP, Sahin M Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder that is characterized by cellular and tissue dysplasia in With the advent of genetic and molecular techniques, mutations in TSC1 or TSC2 genes were discovered to be responsible for mTOR overactivation, which is the underlying mechanism of pathogenesis. TSC is a highly heterogenous clinical entity with variable presentations and severity of disease. The brain, heart, skin, eyes, kidneys, and lungs are commonly involved in this syndrome, with the neurologic symptoms comprising a significant source of mo...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
The task of epileptic focus localization receives great attention due to its role in an effective epileptic surgery. The clinicians highly depend on the intracranial EEG data to make a surgical decision related to epileptic subjects suffering from uncontrollable seizures. This surgery usually aims to remove the epileptogenic region which requires precise characterization of that area using the EEG recordings. In this paper, we propose two methods based on deep learning targeting accurate automatic epileptic focus localization using the non-stationary EEG recordings. Our first proposed method is based on semi-supervised lea...
Source: IEEE Transactions on Biomedical Circuits and Systems - Category: Biomedical Engineering Source Type: research
Publication date: May 2020Source: Epilepsy &Behavior, Volume 106Author(s): Anna Smith, Marte Syvertsen, Deb K. Pal
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways. Biomed Res Int. 2020;2020:6250429 Authors: Kegler A, Caprara ALF, Pascotini ET, Arend J, Gabbi P, Duarte MMMF, Furian AF, Oliveira MS, Royes LFF, Fighera MR Abstract The MnSOD Ala16Val single nucleotide polymorphism (SNP) has been associated with different diseases. However, there are scarcely studies relating this SNP in epilepsy, a neurologic disease that involves some interacting pathways, such as apoptotic and inflammatory...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusions: The most striking feature of this study was the high prevalence of incorrect diagnosis of schizophrenia, with patients not receiving the minimum correct assessment before that diagnosis, resulting in negative consequences. Caution is recommended when diagnosing severely psychotic patients independent of their acute or chronic condition. PMID: 32220147 [PubMed - as supplied by publisher]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Publication date: May 2020Source: Epilepsy &Behavior, Volume 106Author(s): Elena Zambrelli, Katherine Turner, Aglaia Vignoli, Francesca La Briola, Silvia Dionisio, Sara Malanchini, Federica Galli, Maria Paola Canevini
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Discussion Memory is an important part of what distinguishes higher order species from others. Memory also is part of one’s self-identity. Difficulties in short-term memory can make common, everyday tasks difficult for the person experiencing the problem particularly if it recently occurred and the person’s long-term memory is intact. Difficulties with long-term memory can also have problems when language, events or even one’s own identity are affected. For some people the memory loss is temporary but for others, memory impairments are permanent and must be accepted and accommodated as part of the overall...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
z Bassem Sadek Histamine H3 receptors (H3Rs) are involved in several neuropsychiatric diseases including epilepsy. Therefore, the effects of H3R antagonist E177 (5 and 10 mg/kg, intraperitoneal (i.p.)) were evaluated on the course of kindling development, kindling-induced memory deficit, oxidative stress levels (glutathione (GSH), malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD)), various brain neurotransmitters (histamine (HA), acetylcholine (ACh), γ-aminobutyric acid (GABA)), and glutamate (GLU), acetylcholine esterase (AChE) activity, and c-Fos protein expression in pentylenetetrazol...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders involving age-dependent gene dysregulation. Reelin is a glycoprotein that varies its expression throughout lifetime and controls cortical patterning and synaptogenesis. Brain and plasma reelin levels have been reported to be low in adults with autism; as well as in children with autism, but only when compared to control adults. Therefore, reelin expression levels in children with autism are unclear. For this reason, we compared plasma reelin levels in children with autism and children without autism (non-ASD) of similar ages to evaluate reelin expres...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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