Issues and Questions Surrounding Screening for Cognitive Impairment in Older Patients

The importance of addressing age-associated cognitive impairment cannot be overstated. The rising prevalence of cognitive impairment such as mild cognitive impairment (MCI) and dementia, including Alzheimer disease, is becoming a worldwide concern. In this issue of JAMA, the US Preventive Services Task Force (USPSTF) concludes that “the current evidence is insufficient to assess the balance of benefits and harms of screening for cognitive impairment in older adults (I statement).” This recommendation is based on an evidence report and systematic review of the literature that assessed the accuracy of cognitive screening ins truments and the benefits and harms of interventions to treat cognitive impairment. That report represents an update of the previous report on this topic published in 2014.
Source: JAMA - Category: General Medicine Source Type: research

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Conditions:   Dementia;   Alzheimer Disease;   Caregiver Burnout;   Family Members Intervention:   Behavioral: STELLA (Support via TEchnology: Living and Learning with Advancing Alzheimer's disease and related dementias) Sponsors:   Oregon Health and Science University;   National Institute on Aging (NIA) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: This N-of-1 study suggests the Emerald device is feasible to use and can potentially yield actionable data regarding behavioral symptom management. No active or potential device risks were encountered. PMID: 32245677 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
BACKGROUND: Previous evidence suggests that slower gait speed is longitudinally associated with cognitive impairment, dementia and falls in older adults. Despite this, the longitudinal relationship between gait speed, cognition and falls in those with a di...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
CONCLUSIONS: The positive effect of the interaction on the executive function has been observed, specifically in the capacities for planning and sequencing, perceptual organisation, response inhibition, logical reasoning and mental flexibility. PMID: 32242333 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
AbstractVascular dementia (VD) is the second most common cause of dementia following Alzheimer ’s disease (AD). The major symptoms of VD including memory loss, language deficits and impairment of executive functions. Its specific etiology and pathogenesis remain unknown. Currently, treatment options of VD are still limited. The therapeutic strategies aim to control the vascular risk factors and improve the cognitive function. In recent years, cell therapy for neurodegenerative diseases has attracted a great deal of attention. Evidence suggested that stem cell transplantation could improve the symptoms of cerebral inf...
Source: Cell and Tissue Banking - Category: Stem Cells Source Type: research
FRIDAY, April 3, 2020 -- The coronavirus pandemic will put extra stress on caregivers of loved ones with dementias, so the Alzheimer's Foundation of America offers some advice. " Reducing stress is always important for caregivers, and even more so...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
We report the case of a 32 years old man with a family history of  early onset AD associated with a PSEN1 mutation in the exon 4 (I83T). The proband's, carrying the mutation,  present a refractory epilepsy predating cognitive decline. We discuss the physiopathological mechanisms of epilepsy during AD associated with PSEN 1 mutation, the possibility of linking this epilepsy to the mutation?. PMID: 32241222 [PubMed - as supplied by publisher]
Source: Neurocase - Category: Neurology Authors: Tags: Neurocase Source Type: research
AbstractIt has been accepted that kidney function is connected with brain activity. In clinical studies, chronic kidney disease (CKD) patients have been found to be prone to suffering cognitive decline and Alzheimer ’s disease (AD). The cognitive function of CKD patients may improve after kidney transplantation. All these indicators show a possible link between kidney function and dementia. However, little is known about the mechanism behind the relation of CKD and AD. This review discusses the associations b etween CKD and AD from the perspective of the pathophysiology of the kidney and complications and/or concomit...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
CONCLUSIONS: Our study results corroborate earlier findings that the CSF tool is of added value to the diagnostic workup in daily clinical practice outside tertiary referral centers. CSF levels can best be used in patients under 66 years of age. Given the limited use of this tool in settings outside research facilities, we recommend that the usefulness of CSF biomarkers is studied in a multicenter study. When in the future CSF levels can be reliably measured in plasma, this may become even more relevant. PMID: 32224618 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
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