Obsessive-Compulsive Behaviors in Autism —Reply

In Reply Mr Ne ’eman and colleagues raise important points regarding the use of the CYBOCS-PDD in our study. Our trial aimed to investigate a biological concept and provide evidence as to whether fluoxetine could reduce obsessive-compulsive behaviors in children and adolescents with autism spectrum disorders. Cl inicians regularly use these medications, and a Cochrane review had called for proof of their efficacy. The aim was to extend the evidence base and ultimately improve the care of young people with autism spectrum disorders. The CYBOCS-PDD was chosen because of its use in previous studies and evidenc e in this population of sensitivity to change. We also measured anxiety, aberrant and repetitive behaviors, clinical global impressions, and disruptiveness in an effort to broaden the outcome measures.
Source: JAMA - Category: General Medicine Source Type: research

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Across the landscape of mental health research and diagnosis, there is a diverse range of questionnaires and interviews available for use by clinicians and researchers to determine patient treatment plans or investigate internal and external etiologies. Although individually, these tools have each been assessed for their validity and reliability, there is little research examining the consistency between them in terms of what symptoms they assess, and how they assess those symptoms. Here, we provide an analysis of 126 different questionnaires and interviews commonly used to diagnose and screen for 10 different disorder typ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Infection by the parasite Toxoplasma, which affects about 33% of world population, is associated with an increased risk of several mental health disorders, the most strongly with schizophrenia. It is unknown whether schizophrenia is associated with this infection the most strongly, or whether this association has just been the most intensively studied for historical reasons. We used the data from 6,367 subjects tested for toxoplasmosis who took part in an internet survey to search for associations of these infections with 24 mental health disorders and evidence of otherwise impaired mental health. The typical symptom assoc...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ch EA Abstract The impact of externalizing comorbidity on treatment outcome was examined in 104 youth ages 7-16 (M = 11.09 years) with autism spectrum disorder and primary anxiety/obsessive compulsive disorder who completed modular cognitive behavioral therapy (CBT) for anxiety/OCD. Three comorbidity profiles were utilized for group comparisons: participants with oppositional defiant or conduct disorder with attention-deficit hyperactivity disorder (ODD; CD; ADHD; group EXT, n = 25); those without ODD/CD and only ADHD (group ADHD, n = 46); and those without externaliz...
Source: Child Psychiatry and Human Development - Category: Child Development Authors: Tags: Child Psychiatry Hum Dev Source Type: research
Publication date: Available online 29 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Heloísa Helena de Alcantara Barcellos, Aline Pompermaier, Suelen Mendonça Soares, Victoria Costa Maffi, Marina Fernandes, Gessi Koakoski, Karina Kirsten, Bernardo Baldisserotto, Leonardo José Gil BarcellosAbstractEnvironmental pollution caused by antipsychotic residues is a relevant ecological problem. Studies revealed that residues of these drugs are present in a wide range of different ecosystems and can have adverse effects on non-target organisms even in low environmental concentrations. Amon...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Abstract Anxiety is common in children with ASD; however, the burden of specific anxiety disorders for adults with ASD is under-researched. Using the Stockholm Youth Cohort, we compared anxiety disorder diagnoses among autistic adults (n = 4049), with or without intellectual disability, and population controls (n = 217,645). We conducted additional sibling analyses. Anxiety disorders were diagnosed in 20.1% of adults with ASD compared with 8.7% of controls (RR = 2.62 [95% CI 2.47-2.79]), with greatest risk for autistic people without intellectual disability. Rates of almos...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
Becker muscular dystrophy (BMD) results in a decrease of dystrophin with potential implications for cognitive and psychiatric complications. To better understand these concerns, we conducted a retrospective study of the neuropsychological symptoms and respective pharmacotherapies of 74 BMD patients. Eight (10.8%) patients exhibited autistic features, 26 (35.1%) exhibited inattention/hyperactivity, 23 (31.1%) had learning difficulties, 27 (36.5%) had language delays, 9 (12.2%) had global intellectual delays, 4 (5.4%) had features of tics or Tourette's, 27 (36.5%) had emotion dysregulation, 14 (18.9%) had obsessive-compulsiv...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Publication date: Available online 22 August 2019Source: The Lancet PsychiatryAuthor(s): Meng-Chuan Lai, Caroline Kassee, Richard Besney, Sarah Bonato, Laura Hull, William Mandy, Peter Szatmari, Stephanie H AmeisSummaryBackgroundCo-occurring mental health or psychiatric conditions are common in autism, impairing quality of life. Reported prevalences of co-occurring mental health or psychiatric conditions in people with autism range widely. Improved prevalence estimates and identification of moderators are needed to enhance recognition and care, and to guide future research.MethodsIn this systematic review and meta-analysis...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Authors: Zhang RT, Zhou HY, Wang YM, Yang ZY, Wang Y, So SH, Chiu CD, Leung PWL, Cheung EFC, Chan RCK Abstract Schizotypal personality (SP) traits have been found to be correlated with autistic traits, obsessive-compulsive traits, depressive symptoms and anxiety symptoms. However, the overall pattern of the relationship remains unclear. The purpose of this study was to investigate the network structure between SP traits and other subclinical features (symptoms or traits) and test the replicability of these relationships. A total of 2204 college students completed measurements for SP traits, autistic traits, obsessi...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
In conclusion, this review highlights the importance for clinicians to investigate for the presence of chronic nightmares along with other sleep difficulties (most commonly, insomnia and sleep apnea), to consider the potential influence of nightmares on the course of the primary mental disorder, and to be prepared to grant access to treatments targeting nightmares. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
Source: Dreaming - Category: Psychiatry & Psychology Source Type: research
CONCLUSION: The results of this study show that the K-SADS-PL-DSM-5-T is an effective instrument for diagnosing major childhood psychiatric disorders including selective mutism, disruptive mood dysregulation disorder and autism spectrum disorder which have recently been added to the schedule. PMID: 31170306 [PubMed - in process]
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research
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