Tiny Branches —Words That Bring Hope

In this narrative medicine essay, an internist traces the vicissitudes of hope and despair during his wife ’s long battle with breast cancer and highlights how encouraging words from nontreating physicians serve as branches of hope that communicate an unpredictable prognosis.
Source: JAMA - Category: General Medicine Source Type: research

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Contributors : Sabrina Arnold ; Jan Kortland ; Diana V Maltseva ; Timur R Samatov ; Susanne Lezius ; Alexander G Tonevitsky ; Karin Milde-Langosch ; Daniel Wicklein ; Udo Schumacher ; Christine St ürkenSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe effect of Fra-2 overexpression in two stable Fra-2 overexpressing clones of the human breast cancer cell line MDA-MB-231 on survival and metastatic load was studied after subcutaneous injection into scid and E- and P-selectin deficient scid (select) mice. To identify Fra-2 target genes, we performed cDNA microarrays with mRNA isolated from xenograft t...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Obese individuals with breast cancer have a poorer prognosis and higher risk of metastatic disease vs. non-obese patients. Adipose tissue in obese individuals is characterized by an enhanced macrophage infiltration, creating a microenvironment that favors tumor progression. Here, we demonstrate a role for adipocyte-macrophage interactions in the regulation of angiogenesis. Co-culture of THP-1 macrophages with human breast adipocytes led to increased expression of the pro-angiogenic growth factor, vascular endothelial growth factor A (VEGFA). Several adipocyte-derived proteins including leptin, insulin, IL-6, and TNF-&alpha...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Osteoprotegerin (OPG) is a secreted member of the Tumor Necrosis Factor (TNF) receptor superfamily (TNFRSF11B), that was first characterized and named for its protective role in bone remodeling. In this context, OPG binds to another TNF superfamily member Receptor Activator of NF-kappaB Ligand (RANKL; TNFSF11) and blocks interaction with RANK (TNFRSF11A), preventing RANKL/RANK stimulation of osteoclast maturation, and bone breakdown. Further studies revealed that OPG protein is also expressed by tumor cells and led to investigation of the role of OPG in tumor biology. An increasing body of data has demonstrated that OPG mo...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Meta - analysis of prospective studies shows reduced risk for highest versus lowest total fiber intake
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Family Medicine, Gynecology, Internal Medicine, Nursing, Oncology, Journal, Source Type: news
AbstractAltered aerobic glycolysis is a well-recognized characteristic of cancer cell energy metabolism, known as the Warburg effect. Even in the presence of abundant oxygen, a majority of tumor cells produce substantial amounts of energy through a high glycolytic metabolism, and breast cancer (BC) is no exception. Breast cancer continues to be the second leading cause of cancer-associated mortality in women worldwide. However, the precise role of aerobic glycolysis in the development of BC remains elusive. Therefore, the present review attempts to address the implication of key enzymes of the aerobic glycolytic pathway in...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThese results raise the question whether axillary node status is redundant in cases with exceptionally good features, i.e., small tumors with low Ki67, or in those candidate to adjuvant systemic treatment/radiotherapy anyway including TNBC, and support the incorporation of primary BC tumor characteristics as stratification factors in ongoing trials aiming at de-escalating axillary surgical procedures.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Breast Cancer;   Triple Negative Breast Cancer Interventions:   Drug: Carelizumab;   Drug: Nab-paclitaxel;   Drug: Apatinib Sponsor:   Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Breast Cancer Intervention:   Device: cryo-ablation Sponsor:   Fudan University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Breast Cancer;   Brain Metastases Intervention:   Drug: Palbociclib, Trastuzumab, Lapatinib and Fulvestrant Sponsor:   wang shusen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Quality of Life;   Breast Cancer;   Breast Neoplasms Intervention:   Behavioral: quality of life pathway Sponsors:   Tumor Center Regensburg;   German Cancer Aid Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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