Modify treatment for atopic dermatitis when patient response to dupilumab is partial or non-durable

AbstractPatients with moderate-to-severe atopic dermatitis may have partial or non-durable responses to subcutaneous dupilumab, the first targeted systemic agent approved for this indication. Subsequent management approaches in such patients include optimising topical therapy, considering alternative diagnoses, adjusting the dosage of dupilumab dosage and/or using dupilumab in combination with traditional systemic immunosuppressive agents.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research

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Purpose of review The aim of the article is to critically appraise the most relevant studies in the rapidly advancing field of food allergy prevention. Recent findings Epidemiologic studies identified atopic dermatitis as a strong risk factor for food allergy, with mounting evidence for impaired skin barrier and cutaneous inflammation in the pathogenesis. Additional risk factors include a family history of atopy, the timing of allergenic food introduction into the infant's diet, dietary diversity, vitamin D, and environmental factors, such as dog ownership. Early introduction of allergenic foods (such as peanut) into ...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: PAEDIATRICS: Edited by Berthold Koletzko and Raanan Shamir Source Type: research
Contributors : Xuehua Piao ; Ryosuke Miura ; Ryodai Shindo ; Hiroyasu NakanoSeries Type : Expression profiling by arrayOrganism : Mus musculusCellular FLICE-inhibitory protein (cFLIP) prevents the development of dermatitis by blocking TNF α-dependent apoptosis of keratinocytes. However, it is unclear whether TNFα-independent signal might also contribute to the development of dermatitis in epidermis-specific Cflar-deficient (Cflar) mice. Here we show that Cflar;Tnfrsf1a-/- mice were born at the expected Mende lian ratio, but developed severe dermatitis and succumbed soon after birth. Whil...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
IJERPH, Vol. 17, Pages 2404: Contact Allergy—Emerging Allergens and Public Health Impact International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072404 Authors: Uter Werfel Lepoittevin White Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were m...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
We present a case of a 51 ‐year‐old Japanese woman diagnosed with eosinophilic granulomatous polyangiitis (EGPA), a rare vasculitis that can occur in patients with eosinophilia and history of asthma, allergic rhinitis, and sinusitis, with immunoglobulin (Ig) G4 hypergammaglobulinaemia and salivary gland swelling. AbstractA 51 ‐year‐old woman was admitted to our hospital for cough, fever, purpura in the legs, and salivary gland swelling. Six years ago, she had been diagnosed with bronchial asthma and was treated with a combination of inhaled corticosteroid and long‐acting beta2‐agonist. Blood examination showed ...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Conditions:   Atopic Dermatitis;   Pruritus;   Pruritus Chronic;   Dermatitis Interventions:   Drug: Naltrexone;   Other: Placebo Sponsor:   University of Minnesota Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
It is important for healthcare providers to pay attention to parents ’ rearing style and children’s physical symptoms to promote a healthy quality of life among children with atopic dermatitis. We aimed to iden...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
Atopic dermatitis (AD) is known to negatively influence the mental health of patients. However, only a few studies have explored the influencing factors for psychiatric problems among adolescents with AD.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC. PMID: 32218101 [PubMed - as supplied by publisher]
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
Conclusions: For HF-WBI, doses to nTIB over the prescription predicted acute toxicities independent of breast doses. These data support inclusion of TIB as a region of interest in treatment planning and protocol design. PMID: 32214909 [PubMed]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Rep Pract Oncol Radiother Source Type: research
Most cases of allergic contact dermatitis are localized to the area of skin that is exposed to the allergen; however, this is not always the case. When an allergen is ingested it may produce systemic contact dermatitis which is more difficult to diagnose. Unique features of the vulvar epithelium and environment make it susceptible to these reactions.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
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