Cancers, Vol. 12, Pages 514: How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020

Cancers, Vol. 12, Pages 514: How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020 Cancers doi: 10.3390/cancers12020514 Authors: Jacqueline Trouillas Marie-Lise Jaffrain-Rea Alexandre Vasiljevic Gérald Raverot Federico Roncaroli Chiara Villa Adenohypophyseal tumors, which were recently renamed pituitary neuroendocrine tumors (PitNET), are mostly benign, but may present various behaviors: invasive, “aggressive” and malignant with metastases. They are classified into seven morphofunctional types and three lineages: lactotroph, somatotroph and thyrotroph (PIT1 lineage), corticotroph (TPIT lineage) or gonadotroph (SF1 lineage), null cell or immunonegative tumor and plurihormonal tumors. The WHO 2017 classification suggested that subtypes, such as male lactotroph, silent corticotroph and Crooke cell, sparsely granulated somatotroph, and silent plurihormonal PIT1 positive tumors, should be considered as “high risk” tumors. However, the prognostic impact of these subtypes and of each morphologic type remains controversial. In contrast, the French five-tiered classification, taking into account the invasion, the immuno-histochemical (IHC) type, and the proliferative markers (Ki-67 index, mitotic count, p53 positivity), has a prognostic value validated by statistical analysis in 4 independent cohorts. A standardized report for the diagnosis of pituitary tumors, integrating all these parameters, has ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research