Enalapril enhances the anticonvulsant activity of lamotrigine in the test of maximal electroshock.

Conclusions: This study shows that there are no negative interactions between the studied antiepileptic drugs and enalapril or cilazapril. Enalapril even enhanced the anticonvulsant activity of LTG in the MES test in mice that is thought to be a predictive model of human generalized tonic-clonic seizures. PMID: 24145096 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/24145096?dopt=Abstract

Source: Pharmacological Reports - October 23, 2013 Category: Drugs & Pharmacology Authors: Lukawski K, Jakubus T, Janowska A, Raszewski G, Czuczwar SJ Tags: Pharmacol Rep Source Type: research