Effects of age and sex on osteocalcin and bone-specific alkaline phosphatase —reference intervals and confounders for two bone formation markers

AbstractSummaryBone formation markers bone-specific alkaline phosphatase and osteocalcin are used in many clinical situations. Therefore, we calculated reference intervals for the two markers and investigated how they are influenced by several factors including sex and age. Furthermore, we established clinically relevant reference intervals for the two markers.ObjectiveThe bone turnover markers (BTMs), bone-specific alkaline phosphatase (bone ALP), and osteocalcin (OC), are frequently measured formation markers. The purpose of this study was to establish reference intervals (RIs) for the two BTMs in a general adult Danish population.MethodsBone ALP and OC were measured on the iSYS (IDS Plc) automatic analyzer in samples from the Danish Health2006 5-year follow-up study on serum from 2308 participants (54% women, age range 24 –76). Participants with self-reported diagnosis of osteoporosis or receiving hormonal replacement were excluded from analyses while participants on hormonal contraceptives were included.ResultsThe geometric mean and 95%RI for bone ALP were 13.9  μg/L (7.6–25.6) for men and 13.8 μg/L (7.0–27.4) for women, while for OC 16.0 μg/L (7.5–34.4) for men and 18.6 μg/L (8.1–42.9) for women. Levels of bone ALP increased with increasing age (β 1.004,p 
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research

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Background: Aromatase inhibitors (AI ’s) are the gold standard adjuvant treatment for post-menopausal women with oestrogen-receptor positive breast cancer (BC) but accelerate bone loss and increase fracture risk.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: POSTERS B: Lifestyle, Prevention including Secondary Prevention Source Type: research
Objective: Fracture risk increases with age, but few studies focus on persons ≥80 years. In the ACTIVE trial, treatment with abaloparatide for 18 months reduced osteoporotic fracture risk and increased bone mineral density. These effects were maintained with 24 months alendronate treatment in ACTIVExtend. We postulated that similar improvements in bone mineral density and safety would be demonstrated in women ≥80 years. Methods: Post hoc analyses of bone mineral density and fracture incidence in women with osteoporosis at high risk of fracture ≥80 years from ACTIVExtend. Results: In total, 56 women aged &g...
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
Selective estrogen receptor modulators (SERMs) are an increasingly important therapeutic modality that are used by clinicians on a daily basis. Unfortunately, clinicians have a limited understanding regarding the underlying mechanism(s) of how SERMs function and their increasingly useful role in the treatment of estrogen-responsive target tissues such as the breast, bone, vagina, uterine endometrium, and brain. This review will provide a basic understanding of our current knowledge of SERM pharmacodynamics and will highlight the clinical applications of Food and Drug Administration–approved SERMs in the treatment of ...
Source: Menopause - Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research
Many studies demonstrate that earlier menopause is associated with increased risk of cardiovascular disease (CVD): often assumed to be a result of a protracted ageing process. Predictors of earlier menopause include signs of limited ovarian reserve, e.g. low antral follicle count and low anti-Mullerian hormone levels, and have been associated with CVD. Given the close relationship between these ovarian reserve parameters and ovarian response, is it not a surprise thatChristensenet al. (2020) found an association between oocyte yield during assisted reproduction and an increased risk of CVD in their valuable large Danish da...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
talay B Abstract AIM: to evaluate the effect of body composition, nutritional habits (NH), and physical activity (PA) levels on bone mineral density (BMD) in osteoporotic postmenopausal women (OPW). SUBJECTS AND METHOD: the demographic characteristics, anthropometric measurements, PA status, information on NH, some biochemical findings, and BMD measurements of 100 OPWs were evaluated. RESULTS: in this study, 48 % of the women were classified as obese. The obese women were found to have lower vitamin D levels and higher parathyroid hormone levels than those of the over-weight women. A positive correlation...
Source: Nutricion Hospitalaria - Category: Nutrition Authors: Tags: Nutr Hosp Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractSTUDY QUESTIONDo young women with early ovarian ageing (EOA), defined as unexplained, and repeatedly few oocytes harvested in ART have an increased risk of age-related events?SUMMARY ANSWERAt follow-up, women with idiopathic EOA had an increased risk of age-related events compared to women with normal ovarian ageing (NOA).WHAT IS KNOWN ALREADYEarly and premature menopause is associated with an increased risk of cardiovascular diseases (CVDs), osteoporosis and death. In young women, repeated harvest of few oocytes in well-stimulated ART cycles is a likely predictor of advanced menopausal age and may thus serve as an...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
This study aimed to determine the efficacy of isoflavone interventions on bone density outcomes and the safety of isoflavone interventions in postmenopausal women by means of systematic review and meta-analysis.MethodsA systematic search was performed on three databases (PubMed, Scopus, and Cochrane Library). Included studies were limited to randomized controlled trials (RCTs) assessing the effects of isoflavone intervention on bone mineral density (BMD) in postmenopausal women. Mean difference (MD) in BMD or relative risk for adverse outcomes was used as a summary effect measure; pooled-effect estimates were calculated us...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
AbstractThe purpose of this study was to identify risk factors for falls in postmenopausal women and provide evidence for the primary prevention of falls in postmenopausal women. The protocol for this meta-analysis is registered with PROSPERO (CRD42020170927). We searched PubMed, the Cochrane Library and EMBASE for observational studies on the risk factors for falls in postmenopausal women. Review Manager 5.3 was used to calculate the relative risk (RR) or weighted mean difference (WMD) of potential risk factors related to falls. STATA 14.0 was used for the quantitative evaluation of publication bias. Eleven studies with 4...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
This study is the first to provide a direct link between this inflammation and plaque development - by way of IFITM3. Scientists know that the production of IFITM3 starts in response to activation of the immune system by invading viruses and bacteria. These observations, combined with the new findings that IFITM3 directly contributes to plaque formation, suggest that viral and bacterial infections could increase the risk of Alzheimer's disease development. Indeed, researchers found that the level of IFITM3 in human brain samples correlated with levels of certain viral infections as well as with gamma-secretase activ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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