Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Alzheimer Disease

This cross-sectional, longitudinal study of amyloid- β–positive individuals with mild cognitive impairment or Alzheimer disease dementia examines the factors associated with interindividual differences in brain and cognitive resilience to tau positron emission tomography load and to changes in global cognition over time.
Source: JAMA Neurology - Category: Neurology Source Type: research

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Authors: Lyketsos CG Abstract Over 40 million people worldwide suffer from dementia. This number is projected to exceed 110 million by 2050 because of the aging of the worldwide population, especially in lower- and middle-income countries. The most common cause of dementia is believed to be Alzheimer's, a brain disease associated with deposition of beta-amyloid protein and hyperphosphorylation of intraneuronal tau protein leading to synaptic degradation, neuronal loss, brain circuit disruption, a range of symptoms, and eventually, if the person lives long enough, death. Over the last few decades, treatment developm...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
AbstractMultiple studies have investigated the disruptions in structural and functional connectivity in aging, dementia and Alzheimer ’s disease (AD). The study of metabolic connectivity between brain regions using fluorodeoxyglucose positron emission tomography (FDG-PET) however, is a new focus of interest. Several methodological approaches, including seed-based correlation, independent and principal component analysis, and gra ph-theoretical approaches have been employed to study the metabolic disconnectivity in AD. We conducted a systematic search of the literature using the keywords metabolic connectivity and Alz...
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research
Authors: Marinescu RV, Lorenzi M, Blumberg SB, Young AL, Planell-Morell P, Oxtoby NP, Eshaghi A, Yong KX, Crutch SJ, Golland P, Alexander DC Abstract We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only limited, unimodal data is available, by transferring information from larger multimodal datasets from common neurodegenerative diseases. DKT is a joint-disease generative model of biomarker progressions, which exploits bio...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research
Conclusions The results do not support an association between surgical hospitalization and elevated brain amyloid.Editor ’s PerspectiveWhat We Already Know about This TopicHospitalization for medical illness and surgical procedures has been associated with subsequent cognitive decline in some older patientsAnimal models have suggested that surgery and anesthesia may lead to an increased production and accumulation of brain amyloidWhat This Article Tells Us That Is NewThis study found no differences in brain amyloid levels measured by positron emission tomography scans more than a decade after hospitalization for a su...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
CONCLUSIONS: External replacement over guide wire should be considered in such cases. PMID: 32378825 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Conclusion: In methodologically heterogeneous studies of uncertain applicability to typical clinical settings, amyloid PET, 18F-FDG PET, and MRI were highly sensitive for neuropathologic AD. Amyloid PET, 18F-FDG PET, and CSF test combinations may add accuracy to clinical evaluation. Primary Funding Source: Agency for Healthcare Research and Quality. (PROSPERO: CRD42018117897). PMID: 32340038 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
This diagnostic study explores whether positron emission tomography with [18F]flortaucipir can detect tau pathology and Alzheimer disease neuropathologic changes in terminally ill adults with or without dementia.
Source: JAMA Neurology - Category: Neurology Source Type: research
Abstract Personality factors have been associated with Alzheimer's disease (AD) and dementia, but they have not been examined against markers of regional brain glucose metabolism (a primary measure of brain functioning) in older adults without clinically diagnosed cognitive impairment. The relationship between personality factors derived from the five-factor model and cerebral glucose metabolism determined using positron emission tomography (PET) with [18F]-2-fluoro-2-deoxy-D-glucose (18F-FDG-PET) was examined in a cohort of 237 non-demented, community-dwelling older adults aged 60-89 years (M ±...
Source: Brain Structure and Function - Category: Neuroscience Authors: Tags: Brain Struct Funct Source Type: research
AbstractPersonality factors have been associated with Alzheimer ’s disease (AD) and dementia, but they have not been examined against markers of regional brain glucose metabolism (a primary measure of brain functioning) in older adults without clinically diagnosed cognitive impairment. The relationship between personality factors derived from the five-factor m odel and cerebral glucose metabolism determined using positron emission tomography (PET) with [18F]-2-fluoro-2-deoxy-d-glucose (18F-FDG-PET) was examined in a cohort of 237 non-demented, community-dwelling older adults aged 60 –89 years (M &pl...
Source: Anatomy and Embryology - Category: Anatomy Source Type: research
CONCLUSIONS: [¹⁸F]THK5351 PET might be useful for identifying distinct topographic patterns of [¹⁸F]THK5351 retention in subgroups of MCI patients who are at greater risk of the progression to Alzheimer's dementia. PMID: 32319236 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
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