A preliminary study of Parkinson ’s gene therapy via sono-magnetic sensing gene vector for conquering extra/intracellular barriers in mice

Non-virus genetic treatment for Parkinson ’s disease (PD) via plasmid glial cell-line derived neurotrophic factor (pGDNF) has shown potential for repairing damaged dopaminergic neurons. However, development of this gene therapy is largely hampered by the insufficient transfection efficiency as a result of the cell membrane, lysosome, and cytoskeleton meshwork.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 23, 2020 Category: Neurology Authors: Chun-Yao Wu, Rih-Yang Huang, En-Chi Liao, Yu-Chun Lin, Yi-Ju Ho, Chien-Wen Chang, Hong-Lin Chan, Ying-Zu Huang, Tsung-Hsun Hsieh, Ching-Hsiang Fan, Chih-Kuang Yeh Source Type: research