Estimating the Impact of Switching from a Lower to Higher Valent Pneumococcal Conjugate Vaccine in Colombia, Finland, and The Netherlands: A Cost-Effectiveness Analysis

ConclusionIn Colombia, Finland, and The Netherlands, countries with diverse epidemiologic and population distributions, switching from a PCV10 to PCV13 program would significantly reduce the burden of IPD in all three countries in as few as 5  years.
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research

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Purpose of review Mass gathering events bring people from across all continents increasing the risk of spread of aerosol transmissible respiratory tract infections. Respiratory tract infections for instance in pilgrims attending the world's largest recurring annual pilgrimage, the Hajj are common. We review recent literature on viral and bacterial infectious diseases with special focus on the Hajj. Recent findings The prevalence of bacterial and viral infections continue to increase, because of the acquisition of rhinovirus, coronaviruses (229E, HKU1, OC43), influenza A H1N1, Streptococcus pneumoniae, Haemophilus infl...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman and Alimuddin Zumla Source Type: research
Purpose of review This manuscript reviews the recent literature related to new developments in the understanding of existing and novel virulence factors of the pneumococcus that are of potential importance in the development of novel preventive and therapeutic strategies. Recent findings The pneumococcal capsule and pneumolysin have long been recognized as being two of the most prominent virulence factors, with much recent research having revealed previously unrecognized mechanisms by which they contribute to the pathogenesis of infection. Although the pneumococcal capsule has been considered a sine qua non for virule...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman and Alimuddin Zumla Source Type: research
ConclusionsHigher frequency of hematopoietic malignancy in CVID than in the other PADs and association of lower NK cell counts with non-infectious complications in CVID suggest a relationship between immune alterations and the development of non-infectious manifestations in PADs.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
Pneumococcal disease is characterized by diverse clinical manifestations, but the overall burden is dominated by pneumonia which accounted for 15% of all pediatric deaths in 2017 (World Health Organization, 2019). Furthermore, up to 81% of pneumonia deaths occur in the first two years of life and nearly all pneumonia deaths are recorded in low- and middle-income countries, with Sub-Saharan Africa bearing a great share of pneumonia burden (43% of global pneumonia deaths)(Walker et al., 2013). In 2016, pneumonia was the third most frequent cause of visit to hospital outpatient clinics in Burkina Faso, representing 5 ·...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
FOSTER CITY, Calif., March 26, 2020 -- (Healthcare Sales &Marketing Network) -- SutroVax, a biopharmaceutical company dedicated to the delivery of superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious dise... Biopharmaceuticals, Venture Capital SutroVax, conjugate vaccine, vaccine
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
In this study, we report the impact of the pneumococcal conjugate vaccine (PCV), PCV7/PCV13 sequential implementation on serotype distribution, and on the prevalence of piliated strains among carried pneumococci during the pre- and post-vaccine eras. METHODS: During 2002-2016, 12 repeated cross-sectional surveillances of nasopharyngeal S. pneumoniae carriage were conducted among 8,473 children
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
, SIREVA II Group Abstract Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, especially among children and the elderly. S. pneumoniae serotype 19A has emerged as a major cause of invasive disease in many countries, regardless of whether pneumococcal conjugate vaccines are used. The aim of this study was molecular characterization of invasive S. pneumoniae serotype 19A isolates recovered between 2000 and 2015 from 13 National Laboratories through the laboratory-based surveillance of invasive S. pneumoniae program SIREVA II in Latin American countries. The isolates were submitted with a...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Adults with chronic conditions such as heart disease, diabetes, or lung disease are more likely to develop complications from a number of vaccine-preventable diseases, including influenza and pneumonia. In thi...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
Corrigendum to "Impact of the pediatric 13-valent pneumococcal conjugate vaccine on serotype distribution and clinical characteristics of pneumococcal pneumonia in adults: The Japan Pneumococcal Vaccine Effectiveness Study (J-PAVE)" [Vaccine 37 (2019) 2687-2693]. Vaccine. 2020 Mar 19;: Authors: Sando E, Suzuki M, Furumoto A, Asoh N, Yaegashi M, Aoshima M, Ishida M, Hamaguchi S, Otsuka Y, Morimoto K PMID: 32201139 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Public health authorities are advising frequent hand washing and social distancing, especially in the absence of confirmatory testing for COVID-19. I don’t have any wisdom to add to these practices. Vaccines are in the works, as are anti-viral drugs—nothing to add here, either. But let me reiterate what we do in the Wheat Belly and Undoctored lifestyles. In general, we do not treat diseases; we correct the factors that allow disease to emerge in the first place—a big difference. Take rheumatoid arthritis, for example. In conventional healthcare, the joint pain and swelling of rheumatoid arthritis are...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open probiotic undoctored wheat belly Source Type: blogs
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