Frequency, risk factors and outcome of active tuberculosis following allogeneic hematopoietic stem cell transplantation

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment for hematological malignancies and nonmalignant diseases. Furthermore, haploidentical stem cell transplantation has been developed in the past two decades as another potential strategy for patients with no HLA-matched donor.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research

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We report a patient with multifocal PCNSL involving the choroid plexus, who presented with abnormal gait and episodic confusion and memory loss. PCNSL should be considered in the differential diagnosis of acute encephalopathy among immunocompetent older individuals who have choroid plexus enhancing lesions.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Even if the incidence of tuberculosis (TB) has been decreasing over the last years, the number of patients with TB is increasing worldwide. The emergence of multidrug-resistant and extensively drug-resistant TB is making control of TB more difficult. Mycobacterium bovis bacillus Calmette–Guérin vaccine fails to prevent pulmonary TB in adults, and there is an urgent need for a vaccine that is also effective in patients with human immunodeficiency virus (HIV) coinfection. Therefore, TB control may benefit on novel therapeutic options beyond antimicrobial treatment. Host-directed immunotherapies could offer thera...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
We report a case of secondary HLH-related GF in the context of HLA-haploidentical HSCT successfully treated with emapalumab in the presence of concomitant life-threatening infections, including disseminated tuberculosis (TB). A 4 years old girl with Adenosine Deaminase-Severe Combined Immunodeficiency complicated by disseminated TB came to our attention for ex-vivo hematopoietic stem cell-gene therapy. After engraftment failure of gene corrected cells, she received two HLA-haploidentical T-cell depleted HSCT from the father, both failed due to GF related to concomitant multiple infections and secondary HLH. Emapalumab admi...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Conclusions: Patients with mm could benefit from a consistent tst testing policy coupled with subsequent ltbi therapy. However, universal testing might not be required. A targeted program combining evaluation of host risk factors, imaging findings, and screening tests might optimize ltbi diagnosis and management, and thus be effective in preventing the development of active tb in at-risk patients with mm. PMID: 32669929 [PubMed - in process]
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
There is no situation so terrible that it will not be silently accepted as set in stone, only given that it has lasted for long enough to become routine. So it is with aging, and all of the pain, suffering, and death that accompanies it. The present furor surrounding COVID-19 is unusual for casting at least a little light upon the point that infectious disease largely kills older people, and in very large numbers, year in and year out. In the normal course of affairs, no-one cares until it is their turn to be old, frail, and vulnerable. The immune system decays with age, becoming simultaneously overactive (inflammag...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Conclusions: F-18 FDG PET/CT imaging is very beneficial in evaluation of PTLD, particularly in the detection of occult lesions missed on conventional imaging modalities and helped in upstaging the disease in a significant number of patients. Additionally F-18 FDG PET/CT imaging is also helpful in evaluation of clinically suspicious PTLD and can further assist in guiding biopsies for accurate histo-pathological diagnosis.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Leukemia/Lymphoma/Myeloma (Poster Session) Source Type: research
Latent tuberculosis infection (LTBI) is a global health problem estimated to affect at least one out of every four people in the world [1]. Recent changes in sociodemographic paradigms during the latter part of the 20th century, have made of LTBI an important clinical and socioeconomic challenge, particularly in developing countries [2,3]. Incidence of LTBI varies widely between geographical regions, ranging from 3.3 and 11.9 cases per 100,000 individuals in the United States and the European Union, respectively, to 100 cases per 100,000 individuals in Africa [4,5,6].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Original Article Source Type: research
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment for hematologic malignancies and nonmalignant diseases. Furthermore, haploidentical stem cell transplantation has been developed in the past 2 decades as another potential strategy for patients with no HLA-matched donor.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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