Two cases of non-alcoholic fatty liver disease caused by biallelic ABHD5 mutations

Non-alcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease in the developed world, is characterized by hepatic fat accumulation in the absence of significant alcohol or hepatotoxic drug consumption, hereditary diseases and viral infections.1 The multifactorial pathogenesis of NAFLD is associated with lifestyle habits, nutritional factors and genetics. Gene polymorphisms, implicated in fatty acid metabolism are described.1 In case of unexplained NAFLD, further investigations are required to determine the origin of the disease.

Source: Journal of Hepatology - February 23, 2020 Category: Gastroenterology Authors: Isabelle Adant, Mathias Declercq, Matthew Bird, Marijke Bauters, Nancy Boeckx, Koen Devriendt, David Cassiman, Peter Witters Tags: Letter to the Editor Source Type: research