Intestinal flora dysbiosis aggravates cognitive dysfunction associated with neuroinflammation in heart failure

Cognitive impairment is a common central nervous system complication after heart failure (HF), with an incidence as high as 25-75%.1 Cognitive dysfunction seriously affects patient quality of life and imposes a heavy economic burden on society and families. Many factors are involved in the mechanisms underlying cognitive dysfunction after HF. These factors include low cerebral perfusion, abnormal hormone secretion and the immune/inflammatory response.2,3 Several clinical studies have explored the above damage-inducing mechanisms, but no therapeutic effects have been described.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research