Efficacy of Dupilumab in Adolescents With Moderate-to-Severe Atopic Dermatitis With and Without Comorbid Asthma: Subgroup Analysis From a Phase 3 Trial

Atopic dermatitis (AD) is a chronic inflammatory skin disease that presents frequently with other concomitant atopic conditions such as asthma. Dupilumab is approved in the USA for adults and adolescents with inadequately controlled moderate-to-severe AD; as an add-on maintenance treatment for adults and adolescents with inadequately controlled eosinophilic/oral corticosteroid-dependent asthma; and as an add-on maintenance treatment in adults with inadequately controlled chronic rhinosinusitis with nasal polyps.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research

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Atopic dermatitis (AD) is a chronic inflammatory skin disease commonly associated with other atopic conditions such as allergic rhinitis (AR). Dupilumab is approved in the USA for adults and adolescents with inadequately controlled moderate-to-severe AD; as an add-on maintenance treatment for adults and adolescents with inadequately controlled eosinophilic/oral corticosteroid-dependent asthma; and as an add-on maintenance treatment in adults with inadequately controlled chronic rhinosinusitis with nasal polyps.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
In this study we provide evidence for a novel pathway whereby platelets attached to mouse lung ILC2s influence the ability of ILC2s to proliferate and express TH2 cytokines.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research
Go online to PeerView.com/NCE860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, experts in allergy and dermatology discuss advances in the management of allergic and inflammatory diseases presented at the 2019 American Academy of Dermatology Annual Meeting and the American Academy of Allergy, Asthma &Immunology 2019 Annual Meeting. Upon completion of this activity, participants will be able to: Describe the relationship between type 2 inflammatory disorders, including atopic dermatitis, asthma, chronic rhinosinusitis and nasal polyps (CRS/NP), and e...
Source: PeerView CME/CE Audio Podcast - Immunology - Category: Allergy & Immunology Authors: Tags: Science, Medicine Source Type: podcasts
This study was supported by grants from GSK and the UK Medical Research Council (U105178805). Conflict of Interest Statement AM has grant funding from GSK and AstraZeneca/MedImmune. MB, DJ, AP, DT, and AvO are employees of GSK. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We are grateful to the Ares staff, genotyping facility, and flow cytometry core for their technical assistance. We thank Jen Walker for advice on the manuscript. Supplementary Material The Supplem...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 27 March 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Marc Humbert, Jean Bousquet, Claus Bachert, Oscar Palomares, Pascal Pfister, Ioannis Kottakis, Xavier Jaumont, Simon Francis Thomsen, Nikolaos G. PapadopoulosAllergic asthma often coexists with different pathological conditions, called multimorbidities, that are mostly of allergic nature and share a common underlying inflammatory pathophysiological mechanism. Multimorbidities of allergic asthma may influence asthma control, its severity, and patients' response to treatment, and contribute to the ove...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewStaphylococcus aureus (S. aureus) is correlated with the development of persistent severe inflammatory disease of the upper airway including chronic rhinosinusitis with nasal polyps (CRSwNP). The presence ofS. aureus is associated with atopic disease including allergic rhinitis and atopic dermatitis and is associated with poor outcomes.Recent FindingsSeveral different strains ofS. aureus generate different toxins and gene products that can account for organism pathogenicity.S. aureus bacteria and its antigens shape the bacterial and fungal microbiome and the mucosal niche which generates host respo...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
We report results from a phase 3 dupilumab study (SINUS-52;NCT02898454) in severe CRSwNP patients on daily intranasal mometasone furoate (MFNS).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Dupilumab, a human IL-4R- α mAb inhibiting IL-4 and IL-13, key drivers of type 2-mediated inflammation, is approved for uncontrolled moderate-to-severe atopic dermatitis in adults and in the USA for patients aged ≥12 years with moderate-to-severe eosinophilic or oral corticosteroid-dependent asthma. In a phase 2a study, d upilumab improved endoscopic, radiologic, clinical, and patient-reported outcomes in chronic rhinosinusitis with nasal polyps (CRSwNP) patients. For the first time we report results from a phase 3 dupilumab study (SINUS-24; NCT02912468) in severe CRSwNP patients (with/without comorbid asthma) on ...
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Allergic rhinitis (AR) is a condition with a significant impact on patient's quality of life. Sex differences in the prevalence and clinical presentation of rhinitis have been reported in multiple studies. Additionally, it has comorbidities with asthma, atopic dermatitis, rhinosinusitis, otitis media, anosmia, nasal polyps and lower airway infection. As a complex phenotype, AR is affected by both genetic and environmental factors. Recent literature has focused on difference in the genomic architecture of asthma for the two sexes by considering gene-sex interaction, whereas AR has been neglected.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Treatment options for respiratory and dermatologic diseases have expanded considerably during the past 10 years, improving the quality of life of many people with chronic, debilitating, poorly controlled allergic conditions. Some of the most promising are biologic therapies, targeting IgE, interleukin (IL)-5, IL-4, and IL-13. With new monoclonal antibodies being developed and approved at a rapid pace, choosing the best agent for each clinical situation can be a formidable task. This review focuses on monoclonal antibodies for asthma, nasal polyps, urticaria, and atopic dermatitis that are approved by the US Food and Drug A...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: CME Review Source Type: research
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