Mepolizumab Reduces Exacerbations and Improves Health-Related Quality of Life in Patients With Severe Asthma and Nasal Polyps, Sinusitis, or Allergic Rhinitis

We examined the impact of mepolizumab on clinically significant exacerbations and health-related quality of life (HRQoL) in patients with severe eosinophilic asthma and upper respiratory comorbidities.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research

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CONCLUSION: The design results revealed that an optimum exposure of 1:2 of isopropanol: formaldehyde vapours for sixty minutes resulted in desired release of second pulse of dose after a predetermined lag time of 5 hours as desired. '3Cap' system was successful in achieving floating and pulsed release of hypertensive drug opening a 'new lease of life' to the existing drug molecule. PMID: 32484113 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
Authors: Diaz JH Abstract Red meat allergies have followed tick bites on every continent except Antarctica. The sensitizing antigen is galactose-α-1,3-galactose (α-gal), an oligosaccharide constituent of nonprimate blood and meat, acquired by ticks during animal bloodfeeding. Because red meat allergy after tick bites is a worldwide phenomenon, the objectives of this review were to describe the global epidemiology of red meat allergy after tick bites and its immunological mechanisms; to identify the human risk factors for red meat allergy after tick bites; to identify the most common tick vectors of red ...
Source: Southern Medical Journal - Category: General Medicine Tags: South Med J Source Type: research
Additionally, side effects were more common among participants in the HCQ group than the placebo group. One expert says the results raise the question of whether some ongoing trials should stop.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Conclusions: Allergic rhinitis is common comorbidity of asthma that interrelated to asthma control. Identifiable allergens could be detected AR in asthma by SPT. Therefore, reduction of allergens exposure could become preventive approach for asthma patients with AR.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
AbstractPurpose of ReviewStaphylococcus aureus (S. aureus) is correlated with the development of persistent severe inflammatory disease of the upper airway including chronic rhinosinusitis with nasal polyps (CRSwNP). The presence ofS. aureus is associated with atopic disease including allergic rhinitis and atopic dermatitis and is associated with poor outcomes.Recent FindingsSeveral different strains ofS. aureus generate different toxins and gene products that can account for organism pathogenicity.S. aureus bacteria and its antigens shape the bacterial and fungal microbiome and the mucosal niche which generates host respo...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
ConclusionsAn international effort in the implementation of SUA patients registries could help to better understand the clinical features and to manage severe asthma, representing a non negligible socio‐economic burden for health services.This article is protected by copyright. All rights reserved.
Source: Allergy - Category: Allergy & Immunology Authors: Tags: Original Article: Airway Diseases Source Type: research
Conclusions: This study provides evidence that UNGD is associated with nasal and sinus, migraine headache, and fatigue symptoms in a general population representative sample. Citation: Tustin AW, Hirsch AG, Rasmussen SG, Casey JA, Bandeen-Roche K, Schwartz BS. 2017. Associations between unconventional natural gas development and nasal and sinus, migraine headache, and fatigue symptoms in Pennsylvania. Environ Health Perspect 125:189–197; http://dx.doi.org/10.1289/EHP281 Address correspondence to B.S. Schwartz, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Room W7041, Baltimore, MD 21205 USA. Te...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Articles February 2017 Source Type: research
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell li...
Source: World Allergy Organization Journal - Category: Allergy & Immunology Source Type: research
This study evaluates the efficacy of adjuvant leukotriene receptor antagonism in CRS and subtypes. MethodsRetrospective review of collected data at a tertiary‐referral institution. We identified all patients who were prescribed montelukast postoperatively and had a lapse in therapy for at least 1 month (n = 50), so that the patients themselves serve as their own control group. Twenty‐item Sino‐Nasal Outcomes Test (SNOT‐20) scores and Lund‐Kennedy endoscopy scores were obtained for each patient. Scores were compared with and without montelukast using Wilcoxon signed rank test. The analysis was controlled for chang...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: The diagnosis of AR in the epidemiological setting includes heterogeneous upper airway diseases that affect the clinical features of AR and its interactions with asthma.Int Arch Allergy Immunol 2015;168:205-212
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
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