RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA.

CONCLUSIONS Therefore, our results indicate a novel RNPC1/MST1/2 signaling responsible for EC cell stemness. PMID: 32088727 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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AbstractOver 74,000 women in the United States are diagnosed annually with endometrial or cervical cancers and experience significant treatment-related difficulties with body image, sexuality, and sexual functioning. The aims of the research were to examine relationships among body image, sexuality, and sexual functioning, and to understand women ’s views of these concepts. A novel theoretical framework encompassing these three concepts and contextual variables guided the research. A non-experimental cross-sectional pilot study was conducted with pre-menopausal women in an academic medical center who had stages I&nda...
Source: Sexuality and Disability - Category: Disability Source Type: research
Publication date: Available online 23 May 2020Source: Pathology - Research and PracticeAuthor(s): Antonio Raffone, Antonio Travaglino, Marco Cerbone, Caterina de Luca, Daniela Russo, Anna Di Maio, Margot De Marco, Maria Caterina Turco, Luigi Insabato, Fulvio Zullo
Source: Pathology Research and Practice - Category: Pathology Source Type: research
AbstractMost endometrial carcinomas (ECs) occurring during pregnancy are diagnosed in the first trimester. During the gestation period, progesterone level, which has a protective effect on the endometrium, is found to increase. In EC cases, administering high-dose progesterone is a therapeutic strategy because this hormone can considerably shrink tumors. Herein, the case of a woman in whom EC progressed during pregnancy is reported. Before pregnancy, she was diagnosed with atypical polypoid adenomyoma based on a blind office biopsy. She spontaneously conceived 2  months later, although she was suggested to undergo dil...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
In conclusion, MetS is associated with EC risk. PMID: 32439832 [PubMed - as supplied by publisher]
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Conclusion: We conclude the Mayo Clinic Criteria cannot be universally adopted until all four criteria can be validated through a prospective study that includes institutions that have variable resources. PMID: 32425481 [PubMed - in process]
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
Women ’s Health Research at Yale is expanding its work to “address the enduring and pressing medical conditions that continue to affect women’s lives.”
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
When endometrial carcinoma invades the cervical stroma, overall survival and disease-free survival decrease. However, it is still controversial whether patients in suspected stage II should be treated with rad...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Authors: Rosa VL, Garzon S, Gullo G, Fichera M, Sisti G, Gallo P, Riemma G, Schiattarella A Abstract Gynaecological cancer treatment significantly affects the fertility of women in reproductive age. Surgery, chemotherapy and radiotherapy are the mainstays of ovarian, cervical and endometrial cancers and anatomically or functionally impact the uterus and ovaries. Moreover, the sexual function and psychological wellbeing of patients are highly weakened after a cancer diagnosis: depression, anxiety and impairment of quality of life represent a relevant concern for patient care. The potential loss of fertility could be...
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
Authors: Terzic M, Norton M, Terzic S, Bapayeva G, Aimagambetova G Abstract Several different approaches have been designed by physicians in order to preserve fertility in younger patients with endometrial carcinoma. There are various options offering different advantages, but hysteroscopic resection of pathologic endometrial tissue with placement of a Levonorgestrel Intrauterine Device has proven to be the most successful in allowing patients to conceive and give birth afterwards. However, conservative treatments should only be considered in patients with low-grade and low-stage endometrial tumours. There are many...
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
Authors: Liu Y, Lian T, Yao Y Abstract Folate Receptor Alpha (FOLR1), a glycosylphosphatidylinositol-linked protein, is well characterized folate transporters. However, the prognostic power of FOLR1 in cancer remains controversial. We conducted a meta-analysis to assess the prognostic roles of FOLR1 on different cancers. 12 studies involving 4,471 patients were included in this meta-analysis. The pooled analysis indicated that high FOLR1 significantly predicted poor overall survival (OS) [pooled hazard ratio (HR) =0.78, 95% confidence interval (CI) =0.64-0.94, P = 0.009] and the disease-free survival ...
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research
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