Directional deep brain stimulation leads reveal spatially distinct oscillatory activity in the globus pallidus internus of Parkinson's disease patients.

Directional deep brain stimulation leads reveal spatially distinct oscillatory activity in the globus pallidus internus of Parkinson's disease patients. Neurobiol Dis. 2020 Feb 20;:104819 Authors: Aman JE, Johnson LA, Sanabria DE, Wang J, Patriat R, Hill M, Marshall E, MacKinnon CD, Cooper SE, Schrock LE, Park MC, Harel N, Vitek JL Abstract The goal of this study was to characterize the spectral characteristics and spatial topography of local field potential (LFP) activity in the internal segment of the globus pallidus (GPi) in patients with Parkinson's disease utilizing directional (segmented) deep brain stimulation (dDBS) leads. Data were collected from externalized dDBS leads of three patients with idiopathic Parkinson's disease after overnight withdrawal of parkinsonian medication at rest and during a cued reach-to-target task. Oscillatory activity across lead contacts/segments was examined in the context of lead locations and contact orientations determined using co-registered preoperative 7 Tesla (T) MRI and postoperative CT scans. Each of the three patients displayed a unique frequency spectrum of oscillatory activity in the pallidum, with prominent peaks ranging from 5 to 35 Hz, that modulated variably across subjects during volitional movement. Despite subject-specific spectral profiles, a consistent finding across patients was that oscillatory power was strongest and had the largest magnitude of modulation during movement in LFPs recorded fro...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research

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Conclusions The treatment used for PD, particularly DA, is associated with the development of ICDs and related behaviors. Susceptibility to these disorders depends on the associated risk factors. ICDs can have serious personal, family, psychosocial, financial, and medical consequences. However, in contrast, artistic activities have been described in patients with PD while undergoing treatment with DA. These patients are compulsive but report a positive influence on quality of life. These findings highlight the need for a very critical approach at the moment of Dopaminergic Replacement therapy choice. Author Contributio...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study shows the validity of the presented asleep DBS procedure using robot assistance and intraoperative CT verification for accurate electrode placement with shorter operating room times. PMID: 30796551 [PubMed - as supplied by publisher]
Source: Annals of Biomedical Engineering - Category: Biomedical Engineering Authors: Tags: Ann Biomed Eng Source Type: research
Conclusion: We found a small but significant difference in the coordinates calculated on four different devices. These results have to be considered when performing studies comparing active contact locations or when following patients with an implanted DBS lead.Stereotact Funct Neurosurg
Source: Stereotactic and Functional Neurosurgery - Category: Neurosurgery Source Type: research
ConclusionsPeri ‐electrode edema is a common, transient reaction to DBS lead placement and a convincing relation between edema and post‐operative clinical status is lacking.
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Original Article Source Type: research
Manmohan Singh, KV Shabari Girishan, Jitin Bajaj, Kanwaljeet GargNeurology India 2018 66(7):122-130 Parkinson's disease (PD) and dystonia are common indications for the deep brain stimulation (DBS) procedure. It is very important to be diligent about target localization and execution of the procedure. The single most important predictor of a good postoperative outcome is proper patient selection. The various steps of performing DBS include taking a preoperative non - stereotactic MRI, stereotactic frame fixation, fusion of MRI with stereotactic CT scan images, planning of the target and trajectory, lead placement at t...
Source: Neurology India - Category: Neurology Authors: Source Type: research
Abstract OBJECTIVE The authors' aim in this study was to evaluate placement accuracy and clinical outcomes in patients who underwent implantation of deep brain stimulation devices with the aid of frame-based stereotaxy and intraoperative MRI after induction of general anesthesia. METHODS Thirty-three patients with movement disorders (27 with Parkinson's disease) underwent implantation of unilateral or bilateral deep brain stimulation systems (64 leads total). All patients underwent the implantation procedure with standard frame-based techniques under general anesthesia and without microelectrode recording. MR imag...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Most brain surgeons in the U.S. perform the procedure with patients awake the whole time. Not at OHSU.Most surgeons perform deep brain stimulation to ease the effects of Parkinson ’s disease while the patient is awake. Not at Oregon Health&Science University. OHSU neurologists stopped doing awake surgeries in January 2011. They pioneered a technique to accurately map the brain before and during the procedure, allowing the patient to remain asleep with general anesthesia all the while. With DBS, surgeons implant electrodes into specific areas of the brain that control movement in order to improve motor function an...
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
Conclusions:Prelemniscal radiations present an alternative target for DBS in Holmes Tremor. Lower voltage threshold than expected was found. Benefit could be lower power consumption, longer battery life, and less frequent battery replacement.Disclosure: Dr. Foutz has nothing to disclose. Dr. Martinez has nothing to disclose. Dr. Hu has nothing to disclose. Dr. Ko has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Movement Disorders: Tics, Tremor & amp;amp; Ataxia II Source Type: research
CONCLUSIONS: Based on our data, intraoperative CT scan is fast, safe, and a useful tool in the evaluation of the position of the implanted lead. It also reduces the patient's discomfort derived from the transfer of the patient from the operating room to the radiological department. However, intraoperative CT should not be considered as a substitute for postoperative MRI. PMID: 27583182 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
ConclusionTo our knowledge, this is the first reported case of DRAAEP with positive gadolinium enhancement. Despite the extensive contrast enhancement, these DRAAEP appear to remain benign transient events that, in the absence of clinical signs of infection or neurologic decline, may warrant no further aggressive intervention such as hardware removal.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Case Report Source Type: research
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