Research identifies how new cancer treatments can activate tuberculosis infection

(University of Southampton) Researchers at the University of Southampton have identified how new checkpoint inhibitor treatments for cancer can activate tuberculosis in some patients.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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This study provides a comprehensive profiles of genes expressed in response to rifamycin antibiotics towards characterization of their drug interactions with the drugs that are combined to treat various viral, bacterial, fungal and other diseases, including cancer.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Conclusion: These data suggest that tuberculosis remains a major cause of death among people living with HIV/AIDS (PLWHA) in Rio de Janeiro, highlighting the need for studies that identify individual-level factors impacting their survival, thus improving local HIV/AIDS control measures.
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
Authors: Agbo CA, Lawal M, Jibrin D, Enjugu JE Abstract Testicular tuberculosis (TB) is a rare presentation of extrapulmonary TB. A 46-year-old man presented to our Urology clinic with a painless swelling of the right testis. Examination revealed a hard, non-tender swelling on the inferior pole of the testis that measured 3 x 2 cm. Scrotal ultrasound scan showed a complex mass with multiple hypoechoic lesions at the inferior pole of the right testis with dimension 2.4 x 1.7cm. Laboratory data showed elevated alpha fetoprotein and beta hcG and lymphocytosis. A diagnosis of right testicular cancer was made and the pa...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
By ANISH KOKA, MD As the globe faces a novel, highly transmissible, lethal virus, I am most struck by a medicine cabinet that is embarrassingly empty for doctors in this battle.  This means much of the debate centers on mitigation of spread of the virus.  Tempers flare over discussions on travel bans, social distancing, and self quarantines, yet the inescapable fact remains that the medical community can do little more than support the varying fractions of patients who progress from mild to severe and life threatening disease.  This isn’t meant to minimize the massive efforts brought to bear to keep...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: CORVID-19 Health Policy Patients Physicians AIDS Anish Koka AZT coronavirus COVID-19 FDA novel coronavirus Pandemic Source Type: blogs
Over the past 200 years lung diseases have shifted from infections – tuberculosis, pneumonia – to diseases of dirty air – chronic obstructive pulmonary disease, asthma and lung cancer. New diseases have emerged from industrial pollution and HIV infection, while better imaging has revealed others previously unrecognized. Scientific advances in microbiology, im aging and clinical measurement have improved diagnosis and allowed better targeted treatment. Advances in treatment have been dramatic, the most important being drugs (antibiotics, cortisone, β2-adrenoceptor agonists), ventilatory support (from ...
Source: Medicine - Category: Internal Medicine Authors: Tags: Clinical aspects Source Type: research
ConclusionsIn this study we found that many individuals with serious health problems experienced significant physical, emotional, and social suffering due to a lack of access to pain and symptom relief and other essential components of palliative care. Humanitarian responses should develop and incorporate palliative care and symptom relief strategies that address the needs of all people with serious illness-related suffering and their caregivers.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Abstract SUMMARYCurrently, despite the use of a preventive vaccine for several decades as well as the use of effective and well-tolerated viral suppressive medications since 1998, approximately 250 million people remain infected with the virus that causes hepatitis B worldwide. Hepatitis C virus (HCV) and hepatitis B virus (HBV) are the leading causes of liver cancer and overall mortality globally, surpassing malaria and tuberculosis. Linkage to care is estimated to be very poor both in developing countries and in high-income countries, such as the United States, countries in Western Europe, and Japan. In the Unit...
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
A Vaid, C Patil, A Sanghariyat, R Rane, A Visani, S Mukherjee, Alphonsa Joseph, M Ranjan, S Augustine, KP Sooraj, V Rathore, SK Nema, A Agraj, G Garg, A Sharma, M Sharma, K Pansare, C Murali Krishna, Jyotirmoy Banerjee, Sarat ChandraNeurology India 2020 68(1):26-34 Over the last decade, research has intensified worldwide on the use of low-temperature plasmas in medicine and healthcare. Researchers have discovered many methods of applying plasmas to living tissues to deactivate pathogens; to end the flow of blood without damaging healthy tissue; to sanitize wounds and accelerate its healing; and to selectively kill maligna...
Source: Neurology India - Category: Neurology Authors: Source Type: research
ConclusionsThe character of the periosteal reaction is clearly distinguishable from normal bone but is otherwise non ‚Äźspecific, with the exception of distinguishing direct pyogenic bone infection and those not directly related to infection and perhaps allowing identification of renal disease.
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB) and demonstrated its potential to interrogate the host-pathogen interaction (Tezera et al, 2017). Here, we use the model to investigate mechanisms whereby immune checkpoint therapy for cancer paradoxically activates TB infection. In patients, PD-1 is expressed inMycobacterium tuberculosis (Mtb)-infected lung tissue but absent in areas of immunopathology. In the microsphere model, PD-1 ligands are up-regulated by infection, and the PD-1/PD-L1 axis is further induced by hypoxia. Inhibition of PD-1 signalling increases Mtb growth, and augme...
Source: eLife - Category: Biomedical Science Tags: Immunology and Inflammation Source Type: research
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