Genetic Polymorphisms of ABCB11 and ABCB4 in Women With Intrahepatic Cholestasis of Pregnancy (ICP) and in Their First Degree Relatives
Condition: Cholestasis of Pregnancy Intervention: Drug: ursofalk Sponsor: Alexandra Hospital, Athens, Greece Recruiting
ConclusionDue to the heterogeneity of the populations enrolled, the scarcity of the studies that adjusted the CNAPS values for possible confounding factors, and the difficulty in interpreting the published data, no conclusion regarding the statistical robustness and clinical relevance of the data can be made at present. If assayed at the third trimester, the CNAPS have, however, shown better performance, and could be used in populations already at risk of developing complications as suggested by the presence of other clinical features. Other CNAPS, including miRNA, are under investigation, especially for the screening of g...
The ATP binding cassette subfamily B member 4 (ABCB4) gene on chromosome 7 encodes the ABCB4 protein (alias multi drug resistance 3 protein [MDR3]), a P-glycoprotein in the canalicular membrane of the hepatocytes that acts as a translocator of phospholipids into bile. Several variants in ABCB4 have been identified so far that lead to ABCB4 deficiency accounting for a disease spectrum ranging from progressive familial cholestasis type 3 (PFIC-3) to less severe forms presenting as low phospholipid associated cholelithiasis (LPAC), intrahepatic cholestasis of pregnancy (ICP) or drug-induced liver injury (DILI).
Conclusion: The present study supports the concept that ICP is associated with the risk of GDM and preeclampsia. PMID: 32326772 [PubMed - as supplied by publisher]
CONCLUSIONS: ICP is a risk factor for preterm delivery in twin pregnancies. In addition, ICP develops earlier and more frequently in twin pregnancies from IVF-ET than in those from non-IVF twin pregnancies, and the disease may be more serious. PMID: 32198731 [PubMed - as supplied by publisher]
Publication date: Available online 18 February 2020Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Maria Guarino, Valentina Cossiga, Filomena MoriscoAbstractAbnormal liver tests occur in 3-5% of pregnancies and show many different causes. Although alterations of liver enzymes could be a physiological phenomenon, it may also reflect potential severe liver injury, necessitating further assessment and accurate management. The work-up has to consider liver diseases specific of pregnancy and non pregnancy-related liver damage (coincidental and pre-existing to pregnancy).Pre-existing liver diseases during...
Abstract Chronic cholestatic liver disease during pregnancy is rare as diagnosis peaks late in or after reproductive years. As a consequence, there are few studies on this topic. M.Cauldwell and colleagues report maternal and fetal outcome in a retrospective case series of 61 pregnant women with primary biliary cholangitis or primary sclerosing cholangitis (BJOG 2020 xxxx). The collected time span is 20 years including ten different centres, reflecting the relative rarity of these conditions during pregnancy. PMID: 32077233 [PubMed - as supplied by publisher]
Authors: Gao X, Duan X, Cai H, Hu Y, Liu M, Kang K, Zhou M, Fu D, Yi W Abstract Background: The aim of this study was to describe biochemical, virological features and Mother-to child-transmission (MTCT) rate in chronic hepatitis B (CHB) women who stopped antiviral therapy before or in the early pregnancy. Methods: This was a single-center, retrospective study. Forty-three CHB women who stopped treatment before or in the early pregnancy and 103 CHB women with tenofovir disoproxil fumarate (TDF) treatment throughout pregnancy were enrolled. The virological and biochemical flares during pregnancy and postpartum perio...