Brief Update on Dermatologic Uses of Methotrexate Brief Update on Dermatologic Uses of Methotrexate

This review explores established and emerging clinical indications for methotrexate in dermatological conditions, including psoriasis, blistering diseases, chronic urticaria, slceroderma, and more.Skin Therapy Letter
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

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Authors: Kaaz K, Szepietowski JC, Matusiak Ł Abstract Chronic dermatoses, including atopic dermatitis, psoriasis, prurigo nodularis, chronic spontaneous urticaria and hidradenitis suppurativa, as well as accompanying subjective symptoms (itch and pain), have a great impact on patients' well-being. Skin plays an important role in the physiological sleep process. This review attempts to analyze the association between chronic dermatoses in adults and sleep quality in recent studies. Polysomnography and actigraphy are performed for the objective assessment of sleep quality. Questionnaire-based subjective evaluations ...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
AbstractPurpose of ReviewThis paper is intended to review common uses of phototherapy in the treatment of dermatologic disease and to highlight recent updates in the field.Recent FindingsPhototherapy is effective in the treatment of several dermatologic conditions and offers a safe alternative to systemic treatments. Overall, limited studies on the use of phototherapy have been conducted. However, recent studies have demonstrated superior efficacy of various phototherapy options in comparison with other systemic or topical treatments for diseases such as psoriasis, vitiligo, atopic dermatitis, chronic urticaria, mycosis fu...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
Abstract Methotrexate (MTX), an agent originally intended for anti-neoplastic use, has been successfully employed in the treatment of a variety of dermatologic conditions. In addition to its multiple clinical indications, variable dosing and modes of administration make it a viable option for patients of all ages and most comorbidities. MTX is a folate analog that antagonizes dihydrofolate reductase, thus inhibiting thymidylate synthesis and, ultimately, the production of pyrimidine. Depending on dosage, MTX can function as an anti-inflammatory agent, immunomodulator, or antimetabolite. Patients suffering from pso...
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research
CONCLUSION: Many affected individuals seem not to seek an office-based dermatologist when affected by a severe skin condition. Thus, further and more precise studies to identify, address and minimize barriers to optimal patient care are needed. PMID: 31560083 [PubMed - as supplied by publisher]
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Chronic skin diseases have significant impacts on the quality of life (QoL) of the patients, although not life threatening. However, current QoL measurements often do not adequately reflect the actual disease burden of the affected person. Willingness-to-pay (WTP) questionnaire was developed to assess disease burden economically. In this pilot study, we evaluated QoL and WTP in patients with five chronic skin diseases; alopecia areata (AA), atopic dermatitis (AD), chronic urticaria (CU), psoriasis, and vitiligo.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Background: Psoriasis, psoriatic arthritis, atopic dermatitis (AD), hidradenitis suppurativa (HS) and chronic urticaria (CU) are associated with sleep disturbances (SD). Validated, disease-specific instruments are needed to assess SD in these populations. This work focuses on the development of the ‘PsO Sleepy-Q’ for psoriasis and ‘PsA Sleepy-Q’ for psoriatic arthritis.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
The impressive potential of biologics has been demonstrated in psoriasis, hidradenitis suppurativa and urticaria. Numerous biologicals are entering the field for a restricted number of skin disorders. Off-label use of biologics in other recalcitrant skin diseases has increased. Mounting data point to the potential of already existing biologics acting on the IL-17/IL-23 pathway in skin disorders with epidermal hyperkeratosis (e.g. pityriasis rubra pilaris), acneiform inflammation (e.g. hidradenitis suppurativa) and loss of mucosal integrity (e.g. aphthosis). TNF-α blockers are also effective in the latter conditions b...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion Atopic dermatitis (AD) has a prevalence of 3-5% in the overall U.S. population but is increasing with an estimated 10-15% lifetime risk in childhood. It is even more common in children of color with a prevalence in African-American/black children of 17% and Hispanic children of 14%. Health care utilization data also appears to support more severe disease in children of color also. Atopic dermatitis or eczema is a common dermatological skin problem which characteristically is a pruritic, papular eruption with erythema. Like most papulosquamous eruptions it often occurs in intertrigenous areas in people with alle...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus. While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses. IL-31 was originally shown to be produced by activated helper T cells, particularly Th2 cells, mast cells, macrophages and dendritic cells. However, more recent evidence demonstrated that eosinophils are a major source of this cytokine too...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Several lines of evidence indicate that the immune system, inflammation and coagulation are simultaneously activated in autoimmune and immune-mediated skin diseases. Proinflammatory cytokines such as interleukin-6 and tumor necrosis factor-alpha induce the expression of the main initiator of coagulation, i.e. tissue factor. The proteases of coagulation in turn act on protease-activated receptors inducing the expression of various proinflammatory cytokines triggering inflammation. The cross-talk among immune system, inflammation and coagulation amplifies and maintains the activation of all three pathways. This review focuse...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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