In vitro activity of Fosfomycin against mucoid and non-mucoid Pseudomonas aeruginosa strains

ConclusionsOur data suggest that fosfomycin has good effect against mucoid and non-mucoid strains of P. aeruginosa and automated systems can be implemented in clinical microbiology laboratories to assess fosfomycin with rapid and reproducible results.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research

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Abstract The Stenotrophomonas maltophilia complex (Smc) comprises opportunistic environmental Gram negative bacilli responsible for a variety of infections in both humans and animals. Beyond its large genetic diversity, its genetic organization in genogroups was recently confirmed through the whole genome sequencing of human and environmental strains. Animal strains being poorly represented in these analyses, we sequenced the whole genomes of 93 animal strains to determine their genetic background and characteristics. Combining these data with 81 newly sequenced human strains and the genomes available from RefSeq,...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
Antimicrobials have revolutionized the treatment of bacterial infections and saved countless lives, but their improper use is associated with increased healthcare costs, antimicrobial toxicity and antimicrobial-related adverse events, and the global emergence of antimicrobial-resistant bacteria. These issues have been addressed in part through antimicrobial stewardship (AMS) programs. Even in cystic fibrosis (CF), while antimicrobial use has been associated with dramatic improvement in clinical outcomes, there are growing concerns related to antimicrobial resistance (AMR) [1] and worries about limited antimicrobial benefit...
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
ia AM Abstract Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa isolated from cystic fibrosis (CF) patients is further enhanced by the occurrence of hypermutator strains, a hallmark of chronic CF infections. However, the within-patient genetic diversity of P. aeruginosa populations related to antibiotic resistance remains unexplored. Here, we show the evolution of the mutational resistome profile of a P. aeruginosa hypermutator lineage by performing longitudinal and transversal analyses of ...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Antimicrobial resistance (AMR) is commonly observed in bacteria cultured from airways of people with cystic fibrosis (CF) [1]. However, the relevance of AMR to treatment decisions is unclear as there is often discordance between microbiologic test results and clinical response to antibiotic treatment. That is, treatment with an antibiotic to which a cultured pathogen is resistant in vitro does not always predict a poor clinical outcome, and conversely, in vitro susceptibility does not ensure a good clinical outcome [2 –4].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original article Source Type: research
Abstract Patient-derived isolates of the opportunistic pathogen Pseudomonas aeruginosa are frequently resistant to antibiotics due to the presence of sequence variants in resistance-associated genes. However, the frequency of antibiotic resistance and of resistance-associated sequence variants in environmental isolates of P. aeruginosa has not been well studied. Antimicrobial susceptibility testing (ciprofloxacin, ceftazidime, meropenem, tobramycin) of environmental (n=50) and cystic fibrosis (n=42) P. aeruginosa isolates was carried out. Following whole genome sequencing of all isolates, 25 resistance-associated ...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
The development of therapies that modulate or prevent pathogen virulence may be a key strategy for circumventing antimicrobial resistance. Toward that end, we examined the production of pyoverdine, a key virulence determinant, in ~70 Pseudomonas aeruginosa isolates from pediatric cystic fibrosis patients. Pyoverdine production was heterogeneous and showed a clear correlation with pathogenicity in Caenorhabditis elegans and an acute murine pneumonia model. Examination showed pyoverdine accumulation in host tissues, including extrapharyngeal tissues of C. elegans and lung tissues of mice, where accumulation correlated with h...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion: Biofilm formation ability and relatively high frequency of exoS may contribute to the persistence of bacteria within lungs of CF patients. Some characteristics of isolates recovered from a single patient after several sampling procedures were similar, while others lacked resemblance. PMID: 31341563 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
ConclusionsWe show that CF-associatedP. aeruginosa populations can quickly respond to antibiotic therapy and that responses are patient specific. Thus, resistance evolution can be a direct consequence of treatment, and drug efficacy can be lost much faster than usually assumed. The consideration of these patient-specific rapid resistance shifts can help to improve treatment of CF-associated infections, for example by deeper sampling of bacteria for diagnostics, repeated monitoring of pathogen susceptibility and switching between drugs.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Orals Sessions Source Type: research
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Posters Sessions Source Type: research
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