New treatment for adult GH deficiency

According to results from a phase 3 trial published in the Journal of Clinical Endocrinology& Metabolism, a once-weekly growth hormone replacement therapy was effective at treating adults with growth hormone deficiency. Endocrinology Advisor
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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CONCLUSION: The present review emphasizes the pros and cons of phytoestrogens on human health, which may help to direct the pharmaceutical industry to produce various phytoestrongen based drugs against various metabolic disorders. PMID: 32942973 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
ska The value of hops (Humulus lupulus L.) in beer production has been undisputed for centuries. Hops is rich in humulones and lupulones which gives the characteristic aroma and bitter taste, and preserves this golden drink against growing bacteria and molds. Besides α- and β-acids, the lupulin glands of hop cones excrete prenylated flavonoids, which exhibit a broad spectrum of biological activities and therefore has therapeutic potential in humans. Recently, interest in hops was raised due to hop prenylated flavanones which show extraordinary estrogen activities. The strongest known phytoestrogen so...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
ConclusionScreen-detected women and women who had mammograms biennially had lower odds of being diagnosed with high-severity breast cancer, which highlighted the benefit of regular breast cancer screening. Women in subgroups who are more likely to have more severe cancers should be particularly encouraged to participate in regular mammography screening.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
In conclusion, this single disulfide bond loss mutation of a new TPO homozygous mutation, p.Cys655Phe, reduced TPO activity and caused congenital hypothyroidism without affecting subcellular localization of TPO proteins. PMID: 32908504 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
For frozen embryo transplantation patients who failed to use hormone replacement cycle (HRC) transplantation for 2 consecutive times, the third time of transplantation was divided into 2 groups: HRC and natural cycle (NC), and the pregnancy rate of the 2 groups, especially the clinical pregnancy rate, was compared. Retrospective study of 174 patients in the reproductive medicine center of an affiliated hospital of Shandong University of Traditional Chinese Medicine between January 2015 and September 2018. The 174 patients were all infertile with regular menstruation. They had undergone 2 consecutive failed cycles of endo...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
CONCLUSIONS: Although collegiate ATs generally felt competent in treating transgender patients, they did not feel capable of addressing specific aspects of transgender patients' health care needs. Regardless of the resulting perceived unfair advantage, ATs must be aware of the regulations and therapeutic effects associated with hormone-related therapy for transgender student-athletes. PMID: 32905594 [PubMed - as supplied by publisher]
Source: J Athl Train - Category: Sports Medicine Authors: Tags: J Athl Train Source Type: research
Increased doses of levothyroxine may help improve depressive symptoms among older hypothyroid patients receiving hormone replacement therapy.Clinical Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
SummaryThe San Antonio Breast Cancer Summit is one of the most important meetings worldwide for physicians who treat breast cancer. As traveling there is always somewhat of an adventure due to the distance and the time of the year (winter) and access is not easy for all physicians, the goal of this article is to provide an overview of the presentations dealing with hormone-receptor-positive breast cancer, capecitabine, prevention, and hormone replacement therapy. Data and results should positively influence daily practice.
Source: Memo - Magazine of European Medical Oncology - Category: Cancer & Oncology Source Type: research
Authors: Lane LC, Cheetham TD, Perros P, Pearce SHS Abstract Graves' hyperthyroidism is characterised by the presence of autoantibodies that stimulate the thyroid stimulating hormone receptor (TSHR), resulting in uncontrolled secretion of excessive thyroid hormone. Conventional treatments including antithyroid medication, radioiodine or surgery have remained largely unchanged for the past 70 years and either lack efficacy for many patients, or result in lifelong thyroid hormone replacement therapy in the case of the latter two options. The demand for new therapeutic options combined with greater insight into basic ...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
Lingual thyroid should be considered in the differential diagnosis of any base of tongue mass. Examination may reveal worrisome obstructive findings. However, a majority of patients are hypothyroid and respond favorably to hormone replacement therapy upfront. Surgery is reserved for patients unresponsive to medical management or those with severe obstruction. AbstractLingual thyroid should be considered in the differential diagnosis of any base of tongue mass. Examination may reveal worrisome obstructive findings. However, a majority of patients are hypothyroid and respond favorably to hormone replacement therapy upfront. ...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CLINICAL IMAGE Source Type: research
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