Global miRNA and mRNA expression profiles identify miRNA-26a-2-3p dependent repression of IFN signature in systemic sclerosis human monocytes.

In conclusion, our miRNA-mRNA co-sequencing and functional analysis identify miRNA-26a-2-3p as a new candidate which is predicated to negatively regulate ISGs. This implies that reduced expression of miRNA-26a-2-3 may be involved in pathogenic IFN signature in SSc monocytes. This article is protected by copyright. All rights reserved. PMID: 32087087 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Eur J Immunol Source Type: research