Working memory performance with online-tDCS in schizophrenia: A randomized, double-blinded, sham-controlled, partial cross-over proof-of-concept study.

Working memory performance with online-tDCS in schizophrenia: A randomized, double-blinded, sham-controlled, partial cross-over proof-of-concept study. Asian J Psychiatr. 2020 Feb 11;50:101946 Authors: Sreeraj VS, Bose A, Chhabra H, Shivakumar V, Agarwal SM, Narayanaswamy JC, Rao NP, Kesavan M, Varambally S, Venkatasubramanian G Abstract Combining cognitive retraining with transcranial direct current stimulation (tDCS) has been hypothesized to improve cognitive deficits in schizophrenia. The effect of combining a neuropsychological/psychophysiological task with tDCS, called "online-tDCS" for cognitive enhancement in schizophrenia is not rigorously assessed. In this proof-of-concept study, we aimed at evaluating the effect of a single session online-tDCS on working memory(WM) and its transferability to other cognitive functions. Numerical n-back(NNB), digit symbol substitution test(DSST), emotional matching and labelling test(E-MALT), and anti-saccade eye movement beeforefore and after 20 min tDCS (anode: left dorsolateral prefrontal cortex and cathode: left temporoparietal junction) applied during Sternberg's task(WM-task) were assessed. Twenty-three schizophrenia patients with cognitive deficits were randomized to receive either online-tDCS or offline-tDCS (without simultaneous Sternberg's task) sessions. All patients received one session each of active and sham tDCS in a randomized counterbalanced double-blind cross-over design. RMANOVA reveal...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

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Alan Towers wrote an instructive, poignant comment about the difficulty that he had understanding that his schizophrenic son could not be EXPECTED to “make sense”, if sense was defined by the standards that applied for Alan, or for the wider society. Because so many people who live with psychotic illness or substantial neurological impairment require that their affected loved ones operate by THEIR rules and THEIR logical constructs and world view, they often abandon their children, relatives and friends as uncorrectible and irrecoverable, as lost souls. I’ve had a conversation about this subject with a nu...
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - Category: Neuroscience Authors: Tags: Aging and the Brain Alzheimer’s Autism Origins, Treatments Brain Fitness BrainHQ Cognitive Impairment in Children Cognitive impairments Posit Science Schizophrenia, Bipolar Disorder, et alia Source Type: blogs
ConclusionIn this rural African setting, we found little evidence to support the global evidence indicating better course and outcome of schizophrenia in women. Our findings are suggestive of a gendered experience of schizophrenia which varies across contexts. Further investigation is needed due to the important implications for the development of new mental health services in low and middle-income country settings.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
Conditions:   Schizophrenia;   Medication Nonadherence;   Schizo Affective Disorder Interventions:   Behavioral: Customized Adherence Enhancement;   Drug: Haloperidol Decanoate Sponsors:   Case Western Reserve University;   National Institutes of Health (NIH) Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 29 March 2020Source: Schizophrenia Research: CognitionAuthor(s): Suzanne Ho-wai So, Xiaoqi Sun, Gloria Hoi Kei Chan, Iris Hiu Hung Chan, Chui De Chiu, Sherry Kit Wa Chan, Wai Yin Elisabeth Wong, Patrick Wing-leung Leung, Eric Yu Hai Chen
Source: Schizophrenia Research: Cognition - Category: Psychiatry Source Type: research
Schizophrenia is a severe brain disorder that is associated with neurodevelopmental insults, such as prenatal inflammation, that introduce redox-immune-inflammatory alterations and risk for psychotic symptoms later in life. Nutraceuticals may offer useful adjunctive benefits. The aim of this study was to examine the therapeutic effects of Garcinia mangostana Linn (GML) and one of its active constituents, α-mangostin (AM), alone and as adjunctive treatment with haloperidol (HAL) on schizophrenia related bio-behavioral alterations in a maternal immune-activation (MIA) model. Sprague–Dawley dams were exposed to li...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Dopamine is one of the neurotransmitters whose transmission is altered in a number of neural pathways in the brain of schizophrenic patients. Current evidence indicates that these alterations involve hyperactive dopaminergic transmission in mesolimbic areas, striatum, and hippocampus, whereas hypoactive dopaminergic transmission has been reported in the prefrontal cortex of schizophrenic patients. Consequently, schizophrenia is associated with several cognitive and behavioral alterations. Of note, the immune system has been found to collaborate with the central nervous system in a number of cognitive and behavioral functio...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
There is a wealth of evidence showing aberrant functional connectivity (FC) in schizophrenia but with considerable variability in findings across studies. Dynamic FC is an extension of traditional static FC, in that such analyses allow for explorations of temporal changes in connectivity. Thereby they also provide more detailed information on connectivity abnormalities in psychiatric disorders such as schizophrenia. The current study investigated dynamic FC in a sample of 80 schizophrenia patients and 80 matched healthy control subjects, replicating previous findings of aberrant dwell times in specific FC states, and furth...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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Source: Journal of Mental Health - Category: Psychiatry Authors: Source Type: research
AbstractThe recovery movement has revealed that outcomes which focuses on just symptoms and functioning may not be holistic and that consumer-rated outcomes may contribute to a more holistic and person-centric care model. However, a brief and effective measure is required in clinical settings; hence, the aim of the current study is to evaluate the psychometric properties of the briefest personal recovery measure- Mental Health Recovery Measure-10 items, using the CHIME (Connectedness, Hope and optimism about the future, Identity, Meaning in life, Empowerment) personal recovery framework. 64 outpatients with schizophrenia o...
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research
Condition:   Schizophrenia Interventions:   Drug: SEP-363856;   Drug: Placebo Sponsor:   Sumitomo Dainippon Pharma Co., Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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