Molecules, Vol. 25, Pages 996: Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo
Molecules, Vol. 25, Pages 996: Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo
Molecules doi: 10.3390/molecules25040996
Authors:
Gaber El-Saber Batiha
Amany Magdy Beshbishy
Azirwan Guswanto
Arifin Nugraha
Tserendorj Munkhjargal
Mohamed M. Abdel-Daim
Juan Mosqueda
Ikuo Igarashi
Cinnamomum verum is a commonly used herbal plant that has several documented properties against various diseases. The existing study evaluated the inhibitory effect of acetonic extract of C. verum (AECV) and ethyl acetate extract of C. verum (EAECV) against piroplasm parasites in vitro and in vivo. The drug-exposure viability assay was tested on Madin-Darby bovine kidney (MDBK), mouse embryonic fibroblast (NIH/3T3) and human foreskin fibroblast (HFF) cells. Qualitative phytochemical estimation revealed that AECV and EAECV containing multiple bioactive constituents namely alkaloids, tannins, saponins, terpenoids and remarkable amounts of polyphenols and flavonoids. AECV and EAECV inhibited B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi multiplication at half-maximal inhibitory concentrations (IC50) of 23.1 ± 1.4, 56.6 ± 9.1, 33.4 ± 2.1, 40.3 ± 7.5, 18.8 ± 1.6 µg/mL, and 40.1 ± 8.5, 55.6 ± 1.1, 45.7 ± 1.9, 50.2 ± 6.2...
Source: Molecules - Category: Chemistry Authors: Gaber El-Saber Batiha Amany Magdy Beshbishy Azirwan Guswanto Arifin Nugraha Tserendorj Munkhjargal Mohamed M. Abdel-Daim Juan Mosqueda Ikuo Igarashi Tags: Article Source Type: research
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