Serum/plasma homocysteine levels in patients with systemic lupus erythematosus: a systematic review and meta-analysis
This study is to systematically evaluate the association of serum/plasma HCY levels in SLE. A search was done using PubMed, Embase, Web of Science, and ScienceDirect databases up to 7 April 2019. Thirty-six articles including 2919 SLE patients and 3120 healthy controls were finally included in this meta-analysis. The HCY levels were significantly higher in SLE patients than in healthy controls (P <  0.001). The subgroup analysis revealed that Asian, African, Arab, Mixed, White and others as well as ages (<  35 and ≥ 35) had significant higher HCY levels in SLE patients than in the healthy controls. The study indicated that patients with disease activity index scores<  8 (P <  0.001) and ≥ 8 (P = 0.003) of SLE had significant higher HCY levels as compared with the healthy controls. It was also revealed that disease duration in SLE patients for<  10 and ≥ 10 years (P <  0.001) had significant higher HCY levels as compared with the healthy controls. A significant higher HCY level for body mass index (<  23 and ≥ 23) was found as well as measurement type in SLE patients than healthy controls. This meta-analysis demonstrated higher HCY levels in patients with SLE than healthy controls, suggesting a possible role of HCY in the disease.Key Points• Homocysteine (HCY) is closely related to the mechanisms of systemic lupus erythematosus (SLE).• This study reveals a significant correlation between HCY levels and the vario...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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